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TRPM4 抑制剂,9-邻菲罗尔-CAS 484-17-3-Calbiochem

TRPM4 inhibitor, 9-Phenanthrol-CAS 484-17-3-Calbiochem
产品编号:4170041
规格:The TRPM4 inhibitor, 9-Phenanthrol, also referenced under CAS 484-17-3, controls the biological activity of TRPM4. This small molecule/inhibitor is primarily used for Biochemicals applications.
CAS NO:484-17-3
包装规格:50 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
417004150 MG1220
产品别名

484-17-3

TRPM4 抑制剂,9-邻菲罗尔-CAS 484-17-3-Calbiochem

TRPM4 inhibitor, 9-Phenanthrol-CAS 484-17-3-Calbiochem

Phenanthren-9-ol, 9-Hydroxyphenanthrene

基本信息
Empirical Formula【经验(实验)分子式】
C14H10O
Molecular weight
194.23
MDL number
MFCD00082298
General description【一般描述】
A cell permeable hydroxytricyclic derivative that acts as a specific and reversible inhibitor of transient receptor potential melastatin 4 (TRPM4) (IC50 = 20 µM in HEK293 cells). Does not affect TRPM5 and cystic fibrosis transmembrane conductance regulators (CFTR) channels. Decreases the occurrence of early after depolarizations (EAD) and exhibits an anti-arrhythmic effect that is independent of the action of protein kinase A. Shown to abolish NMDA-induced burst firing in dopaminergic neurons. Does not affect K+ currents at ~10 µM, but at higher concentration (~100 µM) it reversibly reduces K+ currents.
Warning【警告】
Toxicity: Irritant (B)
Reconstitution【重悬】
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes【其他说明】
Grand, T., et al. 2008. Brit. Journ. Pharm.153, 1697.
Simard, C., 2012. Brit. Journ. Pharm.165, 2354.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95% (HPLC)
form【形式】
solid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
protect from light
color【颜色】
brown
solubility【溶解性】
DMSO: 50 mg/mL
shipped in【运输】
wet ice
storage temp.【储存温度】
2-8℃
InChI
1S/C14H10O/c15-14-9-10-5-1-2-6-11(10)12-7-3-4-8-13(12)14/h1-9,15H
InChI key
DZKIUEHLEXLYKM-UHFFFAOYSA-N
packaging【包装】
50 mg in Glass bottle
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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