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TRAIL, Human, Recombinant, NSO cells

产品编号:4169997
包装规格:10 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
416999710 μG7910
产品别名

TRAIL, Human, Recombinant, NSO cells

Apo2L; TNF-Related Apoptosis-Inducing Ligand

产品性质
Quality Level【质量水平】
100
recombinant【重组】
expressed in NSO cells
Assay【测定】
≥97% (SDS-PAGE)
form【形式】
lyophilized
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
impurities【杂质】
≤1 EU/μg Endotoxin (EU/μg TRAIL)
shipped in【运输】
ambient
storage temp.【储存温度】
−70℃
packaging【包装】
10 μg in Plastic ampoule
基本信息
General description【一般描述】
Recombinant, human TRAIL expressed in NSO cells a type II transmembrane protein with a C-terminal extracellular domain, which exhibits homology to other TNF family members. Displays potent antitumor activity against selected targets. Induces apoptosis in a number of transformed cell lines but not in normal tissues.
Recombinant, human TRAIL (amino acids 95-281) with an amino-terminal 6X histidine tag and expressed in NSO cells. A type II transmembrane protein with a C-terminal extracellular domain that exhibits homology to other members of this tumor necrosis factor (TNF) family. Displays potent anti-tumor activity against selected targets. Induces apoptosis in a number of transformed cell lines but not in normal tissues. Recombinant bioactive TRAIL is a non-disulfide-linked homotrimer but may contain a small amount (up to 10%) of disulfide-linked homodimers.
Biochem/physiol Actions【生化/生理作用】
ED₅₀ = 4-12 ng/ml as measured by its ability to induce cytotoxicity in mouse L-929 cell line in the presence of metabolic inhibitors actinomycin D
Warning【警告】
Toxicity: Standard Handling (A)
Physical form【外形】
Lyophilized from sterile-filtered PBS, 50 µg BSA/µg TRAIL, pH 7.4.
Reconstitution【重悬】
Reconstitute to ≥20 µg/ml in sterile PBS, 0.1% BSA.
Following reconstitution, refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C or -70°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or up to 3 months at -20°C or -70°C. Avoid freeze/thaw cycles of solutions.
Other Notes【其他说明】
Griffith, T.S., et al. 1999. J. Exp. Med.189, 1343.
Mariani, S.M., et al. 1997. J. Cell Biol.137, 221.
Pan, G., et al. 1997. Science277, 815.
Pan, G., et al. 1997. Science276, 111.
Sheridan, J.P., et al. 1997. Science277, 818.
Pitti, R.M., et al. 1996. J. Biol. Chem.271, 12687.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 1
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