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Thalidomide-Photoswitch3-NH2 hydrochloride
产品别名
Thalidomide-Photoswitch3-NH2 hydrochloride
Photoswitchable protein degrader building block for PROTAC
(E)-N-(4-((4-Aminophenyl)diazenyl)phenyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide hydrochloride
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C27H22N6O6 · xHCl |
Molecular weight | 526.50 (free base basis) |
Application【应用】 | Protein degrader building block Thalidomide-Photoswitch3-NH2 hydrochloride enables the synthesis of PHOtochemically TArgeting Chimeras (PHOTACs), or photoswitchable proteolysis-targeting chimeras (PROTACs) that can be reversibly activated with different wavelengths of light. Developed in the Trauner and Pagano labs, PHOTACs are inactive in the dark but are activated to the cis isomer via irradiation at 390 nm and reversibly deactivated at wavelengths above 450 nm. As described in Reynders et al, this conjugate was used to prepare PHOTAC-I-10 and PHOTAC-II-6 and contains a Cereblon (CRBN)-recruiting ligand, an azobenzene photoswitchable crosslinker, and pendant amine for reactivity with an acid on the target warhead. Light-mediated control of the resulting PHOTAC affords advanced temporal and spatial control of targeted protein degradation. Suggested wavelengths for photoswitching:
Browse our full offering of degrader building blocks that streamlines the synthesis of degrader libraries. Learn more: Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC Degraders for Targeted Protein Degradation |
Other Notes【其他说明】 | PHOTACs enable optical control of protein degradation PhotoPROTACs: A Novel Biotechnology for Cancer Treatment |
Legal Information【法律信息】 | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥95% |
form【形式】 | solid |
storage temp.【储存温度】 | 2-8℃ |
SMILES string | O=C1N(C2C(NC(CC2)=O)=O)C(C3=C1C=CC=C3OCC(NC4=CC=C(/N=N/C5=CC=C(N)C=C5)C=C4)=O)=O.Cl |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |