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STAT5 Inhibitor II, IQDMA-Calbiochem

产品编号:4169290
规格:The STAT5 Inhibitor II, IQDMA controls the biological activity of STAT5.
包装规格:10 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
416929010 MG2380
产品别名

STAT5 Inhibitor II, IQDMA-Calbiochem

N1-(11H-indolo[3,2-c]quinolin-6-yl)-N2,N2-dimethylethane-1,2-diamine

基本信息
Empirical Formula【经验(实验)分子式】
C19H20N4
Molecular weight
304.39
General description【一般描述】
A cell-permeable indoloquinoline compound that exhibits anticancer activity and inhibits the growth of A549 lung cancer cells (IC50 = 8 µM), as well as HL-60 (IC50 = 5 µM) and K562 (IC50 = 8 µM) leukemia cells. IQDMA-mediated apoptosis is shown to correlate with a downregulation of STAT5 pathway signaling in HL-60 and K562 cultures, while JNK and p38 signalings are shown to be activated in A549 cells upon IQDMA treatment.
Warning【警告】
Toxicity: Standard Handling (A)
Reconstitution【重悬】
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes【其他说明】
Su, J.C., et al. 2009, Life Sci.85, 505.
Chien, C.M., et al. 2008, Chem-Biol. Intr.176, 40.
Yang, S.H., et al. 2008, J. Biochem. Mol. Tox.22, 396.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95% (HPLC)
form【形式】
solid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
color【颜色】
brown
solubility【溶解性】
DMSO: 50 mg/mL
shipped in【运输】
ambient
storage temp.【储存温度】
2-8℃
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 2
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