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STAT3 Inhibitor XI, STX-0119-Calbiochem
产品编号: | 4169288 |
规格: | The STAT3 Inhibitor XI, STX-0119 controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
包装规格: | 25 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
STAT3 Inhibitor XI, STX-0119-Calbiochem
N-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C22H14N4O3 |
Molecular weight | 382.37 |
MDL number | MFCD04462306 |
General description【一般描述】 | A cell-permeable oxadiazolyl-quinolinecarboxamide that is shown to selectively suppress STAT3, but not STAT1, STAT5a, or STAT5b, DNA binding activity and prevent IL-6-stimulated STAT3 dimerization in HEK293 cells (by 99% at 100 µM), as well as inhibit the expression of STAT3 target genes both in cultures in vitro (effective conc. 50 µM) and in SCC3-derived tumors in mice in vivo (160 mg/kg/day; p.o.). A cell-permeable oxadiazolyl-quinolinecarboxamide that is shown to selectively suppress STAT3, but not STAT1, STAT5a, or STAT5b, DNA binding activity in nuclear extract from IL-6-stimulated MDA-MB-468 cells (by 74% at 50 µM) and prevent IL-6-stimulated STAT3 dimerization in HEK293 cells (by 50% and 99%, respectively, at 74 and 100 µM), as well as inhibit the expression of STAT3 target genes, c-myc, cyclin D1, and survivin, both in cultures in vitro (effective conc. 50 µM) and in SCC3-derived tumors in mice in vivo (160 mg/kg/day; p.o.). |
Warning【警告】 | Toxicity: Standard Handling (A) |
Other Notes【其他说明】 | Ashizawa, T., et al. 2011. Int. J. Oncol.38, 1245, Matsuno, K., et al. 2010. ACS Med. Chem. Lett.1, 371. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥90% (HPLC) |
form【形式】 | solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | gray to off-white |
solubility【溶解性】 | DMSO: soluble |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | 2-8℃ |
SMILES string | O=C(NC1=NN=C(C2=CC=CO2)O1)C3=CC(C4=CC=CC=C4)=NC5=C3C=CC=C5 |
packaging【包装】 | 25 mg in Glass bottle Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 2 |