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KMO Inhibitor II, JM6-Calbiochem
| 产品编号： | 4157709 |
| 规格： | The KMO Inhibitor II, JM6 controls the biological activity of KMO. This small molecule/inhibitor is primarily used for Neuroscience applications. |
| 包装规格： | 10 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
KMO Inhibitor II, JM6-Calbiochem
Kynurenine-3-Monooxygenase Inhibitor II, JM6, Kynurenine-3-Hydroxylase Inhibitor II, JM6, 2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole, KMO Inhibitor I, Ro 61-8048 Prodrug
基本信息
| Empirical Formula【经验(实验)分子式】 | C23H26N4O6S2 |
| Molecular weight | 518.61 |
| General description【一般描述】 | An orally bioavailable in-vivo prodrug of KMO Inhibitor I, Ro 61-8048 (Cat. No. 420360) that is shown to be metabolically unstable and slowly release Ro 61-8048 in blood and act as a neuroprotectant. Blocks KMO peripherally (IC50 = 4 µM) and sustainingly elevates kynurenic acid (KYNA) brain levels, an antagonist of excitatory amino acid receptors. Shown to prevent synaptic loss and behavioral deficits in AD and HD mouse model and increase the survival. |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Campesan, S., et al. 2011. Chem. Biol.21, 961. Zwilling, D., et al. 2011. Cell145, 863. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | powder |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: 5 mg/mL |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 10 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
