Interferon-α-IFNα-R Interaction Inhibitor-Calbiochem

C₁₈H₁₇NS · xHCl

279.40 (free base basis)

A nonpeptidic thiophenylmethanamine compound that binds interferon-α (K_d = 4 µM for human IFN-α) and prevents IFN-α and IFNAR interaction-dependent IFN-α production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA infection (IC₅₀<4.5 µM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (≤4.5 µM).
A nonpeptidic thiophenylmethanamine compound that binds interferon-α (K_d = 4 µM for human IFN-α) and prevents IFN-α and IFNAR interaction-dependent IFN-α production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA (vaccinia virus Ankara) infection (IC₅₀<4.5 µM), TLR9 ligand CpG2216 stimulation, VSV-M2 (vesicular stomatitis virus variant 2) infection, or MDA5/TLR3 ligand poly(I:C) stimulation (by >95% inhibition at 9 µM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (≤4.5 µM).

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Geppert, T., et al. 2011. Angew. Chem. Int. Ed.51, 258.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)
protect from light

white

DMSO: 50 mg/mL, clear, colorless

ambient

−20℃

CNCC1=CC=CC=C1SC2=CC=CC3=C2C=CC=C3.[xHCl]

25 mg in Glass bottle
Packaged under inert gas

11 - Combustible Solids

WGK 2