InSolutionBestatin, Hydrochloride-Calbiochem

C₁₆H₂₄N₂O₄ · xHCl

308.37 (free base basis)

A metalloprotease inhibitor. Reversibly binds to cell surfaces and competitively inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase. Also acts as a potent aminopeptidase N inhibitor. Activates macrophages and T lymphocytes. Has anti-tumor properties. Effective at a concentration of 1-10 µM. The solid form of this compound (Cat. No. 200484) is also available.

Primary Target
Metalloproteases
Cell permeable: no
Reversible: yes

Toxicity: Standard Handling (A)

Supplied as a 50 mM (10 mg/580 µL) solution of Bestatatin, HCl in H₂O.

Following initial, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Merck Index: 14, 9842.
Inoue, T., et al. 1994. J. Clin. Endocrinol. Metab.79, 171.
Taylor, A., et al. 1993. Biochemistry32, 784.
Ishida, J.I., et al. 1984. J. Chromatogr.305, 381.
Umezawa, H. 1982. Annu. Rev. Microbiol.36, 75.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

liquid

Calbiochem^®

OK to freeze
avoid repeated freeze/thaw cycles
protect from light

dry ice

−20℃

CC(C)C[C@@H](C(O)=O)NC([C@@H](O)[C@H](N)CC1=CC=CC=C1)=O.[xHCl]

10 mg in Glass bottle
Packaged under inert gas

12 - Non Combustible Liquids

WGK 2