InSolution Rac1 Inhibitor II, Z62954982-CAS 1090893-12-1-Calbiochem

C₂₀H₂₁N₃O₅S

415.46

MFCD11736677

A cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 µM) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1. Shown to effectively prevent PDGF-BB-induced membrane ruffling and lamellipodia formation in serum-starved 3T3 cells (4 h pretreatment at 25 µM). The solid form of this compound (Cat. No. 553511) is also available.

Toxicity: Irritant (B)

A 100 mM (10 mg/241 µl) solution of Rac1 Inhibitor II, Z62954982 (Cat. No. 553511) in DMSO

Following initial thaw, aliquot and freeze (-20°C).

Ferri, N., et al. 2009. J. Med. Chem.52, 4087.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥93% (HPLC)

liquid

Calbiochem^®

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

ambient

−20℃

CC1=CC=C(NC(C2=CC(OCC3=C(C)ON=C3C)=CC=C2)=O)C=C1S(N)(=O)=O

10 mg in Glass bottle
Packaged under inert gas

10 - Combustible liquids

WGK 3

188.6 °F - (refers to pure substance)

87 ℃ - (refers to pure substance)