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InSolution Fluvastatin, Sodium Salt-CAS 93957-55-2-Calbiochem
| 产品编号： | 4157513 |
| 规格： | A synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent. |
| CAS NO： | 93957-55-2 |
| 包装规格： | 10 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4157513 | 10 MG | 1940 |
产品别名
93957-55-2
InSolution Fluvastatin, Sodium Salt-CAS 93957-55-2-Calbiochem
(±)-(3R',5S',6E)-7-(3-(4-Fluorophenyl)-1-isopropylindol-2-yl)-3,5-dihydroxy-6-heptenoate, sodium
基本信息
| Empirical Formula【经验(实验)分子式】 | C24H25FNNaO4 |
| Molecular weight | 433.45 |
| MDL number | MFCD08063391 |
| General description【一般描述】 | A synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent. Unlike Lovastatin (Cat. No. 438185), Mevastatin (Cat. No. 474700), and Simvastatin (Cat. No. 567020), it does not require activation prior to use for in vitro studies. Reduces the basal MMP-1 levels in culture media of endothelial cells in a time- and dose-dependent manner. Fluvastatin is metabolized in the liver, primarily via hydroxylation of the indole ring at the 5- and 6-positions. N-Dealkylation and β-oxidation of the side-chain also occurs. The hydroxy metabolites are also reported to have some pharmacologic activity. |
| Biochem/physiol Actions【生化/生理作用】 | Reversible: yes |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Physical form【外形】 | A 10 mM (10 mg/2.13 ml) solution of Fluvastatin, Sodium Salt (344095) in H₂O. |
| Other Notes【其他说明】 | Yamamoto, A., et al. 2001. J. Pharm. Pharmacol.53, 227. Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol.52, 145. Ikeda, U., et al. 2000. Hypertension36, 325. Levy, R.I., et al. 1993. Circulation87 (4 Suppl.), III45. Tse, F.L.S. et al. 1992. J. Clin. Pharmacol.32, 630. Yuan, J., et al. 1991. Atherosclerosis87, 147. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles protect from light |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| InChI | 1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;/t18-,19-;/m0./s1 |
| InChI key | ZGGHKIMDNBDHJB-RPQBTBOMSA-M |
| packaging【包装】 | 10 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
