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FeTMPyP-Calbiochem

产品编号:4156859
规格:Catalyzes the isomerization of peroxynitrite (ONOO-) to nitrate (NO3-) under physiological conditions and at realistic dose-derived concentrations (kcat = 2.2 x 106M-1s-
包装规格:10 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
415685910 MG1410
产品别名

FeTMPyP-Calbiochem

5,10,15,20-Tetrakis(N-methyl-4'-pyridyl)porphinato Iron (III) Chloride, Fe IIITMPyP(Cl)

基本信息
Empirical Formula【经验(实验)分子式】
C44H36Cl5FeN8
Molecular weight
909.92
General description【一般描述】
Catalyzes the isomerization of peroxynitrite (ONOO-) to nitrate (NO3-) under physiological conditions and at realistic dose-derived concentrations (Kcat = 2.2 x 106 M-1s-1). Effectively prevents the oxidation of lipid components by peroxynitrite. Also decomposes superoxide radicals (O2) catalytically. Irradiation of the aqueous solution at 335 nm releases hydroxyl (OH) radicals. FeTMPyP can also serve as a potential drug for reactive oxygen species (ROS) detoxification.
Catalyzes the isomerization of peroxynitrite (ONOO) to nitrate (NO3) under physiological conditions and at realistic dose-derived concentrations (Kcat = 2.2 x 106 M-1s-1). Effectively prevents the oxidation of lipid components by peroxynitrite. Also catalytically decomposes superoxide radicals (O2·). Irradiation of the aqueous solution at 335 nm releases hydroxyl (OH·) radicals. FeTMPyP can also serve as a potential for drug detoxification of reactive oxygen species (ROS).
Biochem/physiol Actions【生化/生理作用】
Kcat = 2.2 x 106 M-1s-1 in catalyzing the isomerization of peroxynitrite (ONOO-) to nitrate (NO3-) under physiological conditions
Primary Target
Peroxynitrite (ONOO-)
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Warning【警告】
Toxicity: Standard Handling (A)
Reconstitution【重悬】
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Other Notes【其他说明】
Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 7493.
Hunt, J.A., et al. 1997. Chem. Biol. 4, 845.
Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
Stern, M.K., et al. 1996. J. Am. Chem. Soc. 118, 8735.
Faraggi, M., et al. 1984. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.46, 703.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥90% (TLC)
form【形式】
solid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
desiccated (hygroscopic)
protect from light
color【颜色】
brown
solubility【溶解性】
water: 50 mg/mL
shipped in【运输】
ambient
storage temp.【储存温度】
−20℃
packaging【包装】
10 mg in Plastic ampoule
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 1
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