ETYA-CAS 1191-85-1-Calbiochem

C₂₀H₂₄O₂

296.40

MFCD00036967

Cell permeable. Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases. Inhibits phospholipase A₂ (PLA₂) and cytochrome P-450. Inhibits cyclooxygenase (ID₅₀ = 8 µM), 5-lipoxygenase (ID₅₀ = 10 µM), 12-lipoxygenase (ID₅₀ = 300 nM), and 15-lipoxygenase (ID₅₀ = 200 nM) in whole cells. Also acts as a potent modulator of Ca²⁺ entry into cells. Blocks monocyte binding in minimally-oxidized LDL in endothelial cells. Stimulates luteinizing hormone release from cultured pituitary cells.
Cell-permeable. Inhibits arachidonic acid uptake and arachidonic acid specific and nonspecific acyl-CoA synthesis. Inhibits phospholipase A₂ (PLA₂) and cytochrome P-450. Inhibits cyclooxygenase (ID₅₀ = 8 µM), 5-lipoxygenase (ID₅₀ = 10 µM), 12-lipoxygenase (ID₅₀ = 300 nM), and 15-lipoxygenase (ID₅₀ = 200 nM) in whole cells. A potent modulator of Ca²⁺ entry into cells. Stimulates luteinizing hormone release from cultured pituitary cells.

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 8 µM, 10 µM, 300 nM, 200 nM against cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, and 15-lipoxygenase , respectively, in whole cells
Primary Target
PLA₂

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Honda, H.M., et al. 1999. Arterioscler. Thromb. Vasc. Biol.19, 680.
Ekokoski, E., and Tornquist, K. 1994. Biochim. Biophys. Acta 1223, 274.
Ondrey, F., et al. 1989. Cancer Res.49, 1138.
Kuhn, H., et al. 1984. Eur. J. Biochem.139, 577.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (TLC)

solid

Calbiochem^®

OK to freeze

off-white

ethanol: 20 mg/mL
DMSO: soluble

ambient

−20℃

1S/C20H24O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-5,8,11,14,17-19H2,1H3,(H,21,22)

MGLDCXPLYOWQRP-UHFFFAOYSA-N

20 mg in Plastic ampoule

11 - Combustible Solids

WGK 3