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E7820-PEG3-NH2 hydrochloride
产品别名
E7820-PEG3-NH2 hydrochloride
DCAF15 protein degrader building block
Crosslinker–E3 Ligase ligand conjugate
N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-3-(N-(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl)benzamide hydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C25H31N5O6S · xHCl |
| Molecular weight | 529.61 (free base basis) |
| Application【应用】 | Protein degrader builiding block E7820-PEG3-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. This conjugate contains a DCAF15-recruiting ligand E7820 (SML2950 ), a PEG linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Protein Degrader Building Blocks Technology Spotlight: DCAF15 Degrader Building Blocks for Targeted Protein Degradation |
| Other Notes【其他说明】 | In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15 E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones |
| Legal Information【法律信息】 | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
产品性质
| form【形式】 | amorphous powder |
| Quality Level【质量水平】 | 100 |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
