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CXCR7 Agonist, VUF11207-Calbiochem
产品编号: | 4156369 |
规格: | The CXCR7 Agonist, VUF11207 controls the biological activity of CXCR7. This small molecule/inhibitor is primarily used for Biochemicals applications. |
包装规格: | 10 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
CXCR7 Agonist, VUF11207-Calbiochem
(E)-N-(3-(2-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide, RDC1 agonist, CMKOR1 Agonist, CXCR-7 Agonist, CXC-R7 Agonist, RDC-1 Agonist, GPR159 Agonist
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C27H35FN2O4 |
Molecular weight | 470.58 |
MDL number | MFCD23136023 |
General description【一般描述】 | A styrene-amide derivative that acts as a high affinity and high potency ligand of CXCR7 chemokine receptor (pKi = 8.1) and induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7. Exposure of HEK293 T cells transiently transfected with cDNA encoding both CXCR7-RLuc and β-arrestin 2-YFP to VUF11207 is shown to induce a dose-dependent increase in bioluminescence resonance energy transfer (BRET) signal (EC50 = 1.6 nM) indicating its agonist role in β-arrestin2 is recruited to the active receptor. |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target CXCR7 Reversible: yes |
Warning【警告】 | Toxicity: Standard Handling (A) |
Other Notes【其他说明】 | Wijtmans, M., et al. 2011, Eur J Med Chem51, 184. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥99% (HPLC) |
form【形式】 | oil |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | light yellow |
solubility【溶解性】 | DMSO: 50 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | −20℃ |
SMILES string | O=C(N(CCC1N(C)CCC1)C/C(C)=C/C2=C(F)C=CC=C2)C3=CC(OC)=C(OC)C(OC)=C3 |
packaging【包装】 | 10 mg in Glass bottle Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 2 |