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C5 Lenalidomine-C3-NH2 hydrochloride
产品别名
C5 Lenalidomine-C3-NH2 hydrochloride
Protein degrader building block for PROTAC research
4-Amino-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)butanamide hydrochloride
C5 Lenalidomide conjugate
Crosslinker-E3 Ligase ligand conjugate
Template for synthesis of targeted protein degrader
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C17H20N4O4 · xHCl |
Molecular weight | 344.37 (free base basis) |
Application【应用】 | Protein degrader builiding block C5 Lenalidomide-C3-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand with alternative exit vector and an alkyl-chain crosslinker with pendant amine for reactivity with an acid on the target warhead. Because even slight alterations in ligands, warheads, and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. |
Other Notes【其他说明】 | Degrader Building Blocks for Targeted Protein Degradation Building PROTAC® Degraders for Targeted Protein Degradation Targeted Protein Degradation by Small Molecules Small-Molecule PROTACS: New Approaches to Protein Degradation Targeted Protein Degradation: from Chemical Biology to Drug Discovery |
Legal Information【法律信息】 | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥95% |
form【形式】 | powder or crystals |
storage temp.【储存温度】 | 2-8℃ |
SMILES string | O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(CCCN)=O)=CC=C31.Cl O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(CCCN)=O)=CC=C31.Cl |
安全信息
Pictograms【象形图】 | GHS08 |
Signal word【警示用语:】 | Warning |
Hazard Statements | H361d - H373 |
Precautionary Statements | P201 - P308 + P313 |
Hazard Classifications【危险分类】 | Repr. 2 - STOT RE 2 |
Target Organs【靶器官】 | Blood |
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 1 |