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Anti-SRY, clone 1G4 Antibody
产品别名
Anti-SRY, clone 1G4 Antibody
Sex-determining region Y protein, Testis-determining factor, SRY
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | Sex-determining region Y protein, also known as Testis-determining factor, and encoded by the human gene SRY or TDF is a transcriptional regulator that controls a genetic switch in male development. SRY is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) to Sertoli rather than granulosa cells. In male adult brain SRY is involved in the maintenance of motor functions of dopaminergic neurons. SRY is also involved in different aspects of gene regulation including promoter activation or repression, DNA bending and manipulation. The SRY HMG box recognizes DNA by partial intercalation into the minor groove, and SRY is also involved in pre-mRNA splicing. SRY is expressed in the developing testis and surrounding tissue and can be found expressed in neurons in the adult. SRY is nuclear associated. |
Immunogen【免疫原】 | Purified recombinant fragment of human SRY expressed in E. Coli |
Application【应用】 | Research Category Neuroscience Anti-SRY, clone 1G4 Antibody is an antibody against SRY for use in western blotting, IHC, flow cytometry & ELISA. Research Sub Category Developmental Neuroscience Immunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected SRY in cervical and ovarian cancer tissues. Flow Cytometry Analysis: A 1:200-400 dilution from a representative lot detected SRY in HepG2 cells. ELISA: A representative lot detected control Antigen (100 ng) and Antigen (10 ng, 50 ng, 100 ng) in ELISA (Direct). |
Quality【质量】 | Evaluated by Western Blotting in NTERA-2 cell lysate. Western Blotting Analysis: A 1:500-2,000 dilution of this antibody detected SRY in NTERA-2 cell lysate. |
Physical form【外形】 | Purified mouse monoclonal in PBS containing up to 0.1% sodium azide and 0.5% protein stabilizer. Format: Purified Protein G Purified |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
antibody form【抗体形式】 | purified antibody |
antibody product type | primary antibodies |
clone【克隆】 | 1G4, monoclonal |
species reactivity | human |
technique(s) | ELISA: suitable flow cytometry: suitable immunohistochemistry: suitable western blot: suitable |
isotype【同位素/亚型】 | IgG1 |
UniProt accession no.【UniProt登记号】 | Q05066 |
shipped in【运输】 | wet ice |
Gene Information | human ... SRY(6736) |
产品说明
Target description【目标描述】 | ~36 kDa observed. Uncharacterized bands may be observed in some lysate(s). |
Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 2 |