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Anti-Sox10 Antibody
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | Sox 10 is part of a family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Sox 10 is expressed in multipotent neural crest stem cells, and its expression is downregulated upon their differentiation. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. |
Specificity【特异性】 | Sox10. The immunogen sequence is 70% conserved with Sox8 and Sox9 and therefore the antibody may show cross reactivity to these proteins. |
Immunogen【免疫原】 | Synthetic peptide from Sox10. |
Application【应用】 | Research Category Neuroscience Western blot: 0.1-0.5 μg/mL using ECL on fetal mouse brain tissue lysate. The antibody reacts with proteins of ~60 kDa. An additional band of ~120 kDa may also be seen depending on sample used. Optimal working dilutions must be determined by the end user. Anti-Sox10 Antibody detects level of Sox10 & has been published & validated for use in WB. Research Sub Category Developmental Neuroscience Neuronal & Glial Markers |
Linkage【联系】 | Replaces: AB5774 |
Physical form【外形】 | Affinity purified immunoglobulin. Liquid. |
Legal Information【法律信息】 | CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody form【抗体形式】 | affinity purified immunoglobulin |
clone【克隆】 | polyclonal |
purified by【纯化方式】 | affinity chromatography |
species reactivity | mouse |
manufacturer/tradename | Chemicon® |
technique(s) | western blot: suitable |
NCBI accession no.【NCBI登记号】 | NM_006941.3 |
UniProt accession no.【UniProt登记号】 | P56693 |
shipped in【运输】 | wet ice |
产品说明
Target description【目标描述】 | Approx. 55 kDa |
Storage and Stability【储存及稳定性】 | Maintain at +2-8°C in undiluted aliquots for up to 6 months after date of receipt. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 2 |