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Anti-Prdx-6 Antibody, clone TAG-2A12

产品编号:4154846
规格:clone TAG-2A12, from mouse
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4154846100 μG3500
产品别名

Anti-Prdx-6 Antibody, clone TAG-2A12

Peroxiredoxin-6, EC: 1.11.1.15, 1-Cys peroxiredoxin, 1-Cys PRX, 24 kDa protein, Acidic calcium-independent phospholipase A2, aiPLA2, Antioxidant protein 2, Liver 2D page spot 40, Non-selenium glutathione peroxidase, NSGPx

基本信息
eCl@ss
32160702
General description【一般描述】
Peroxiredoxin-6 (UniProt: P30041; also known as EC: 1.11.1.15, 1-Cys peroxiredoxin, 1-Cys PRX, 24 kDa protein, Acidic calcium-independent phospholipase A2, aiPLA2, Antioxidant protein 2, Liver 2D page spot 40, Non-selenium glutathione peroxidase, NSGPx) is encoded by the PRDX6 (also known as AOP2, KIAA0106) gene (Gene ID: 9588) in human. Peroxiredoxin-6 is a cytoplasmic protein that is involved in redox regulation of the cell. It reduces hydrogen peroxide and short chain organic fatty acid, and phospholipid hydroperoxides. It is the only mammalian 1-Cys member of the Prdx family with bifunctional - glutathione peroxidase and phospholipase A2 activities. Peroxiredoxin-6 shares several structural and functional properties with other members of the Prdx family, however, it has only one conserved cysteine residue and its thioredoxin does not participate in the catalytic cycle. Peroxiredoxin-6 is expressed in higher levels in epithelium such as apical regions of respiratory epithelium and skin epidermis and within the lung, it is expressed at relatively high levels within the type II alveolar epithelial cells and bronchiolar Clara cells. Lower levels of expression are reported in alveolar macrophages and microvascular endothelium. Human peroxiredoxin-6 shares 87% sequence identity with mouse, rat, and bovine.
Specificity【特异性】
Clone TAG-2A12 detects Peroxiredoxin-6 in human cells.
Immunogen【免疫原】
Corneal endothelial cells (hCENC) isolated from corneas of human cadavers and immunized with monophosphoryl-lipid A trehalose dicorynomycolate (MPLCTDM) adjuvant.
Application【应用】
Anti-Prdx-6 Antibody, clone TAG-2A12, Cat. No. MABN1797, is a highly specific mouse monoclonal antibody that targets Prdx-6 and has been tested in Flow Cytometry, Immunofluorescence, Immunocytochemistry and Immunoprecipitation, and Western Blotting.
Immunoprecipitation Analysis: A representative lot detected Prdx-6 in Immunoprecipitation applications (Ding, V., et al. (2014). MAbs. 6(6):1439-52).

Immunocytochemistry Analysis: A representative lot detected Prdx-6 in Immunocytochemistry applications (Ding, V., et al. (2014). MAbs. 6(6):1439-52).

Flow Cytometry Analysis: A representative lot detected Prdx-6 in Flow Cytometry applications (Ding, V., et al. (2014). MAbs. 6(6):1439-52).

Immunofluorescence Analysis: A representative lot detected Prdx-6 in Immunofluorescence applications (Ding, V., et al. (2014). MAbs. 6(6):1439-52).

Western Blotting Analysis: A representative lot detected Prdx-6 in Western Blotting applications (Ding, V., et al. (2014). MAbs. 6(6):1439-52).

Flow Cytometry Analysis: A representative lot detected Prdx-6 in human corneal endothelial cells from a donor. (Courtesy of Dr. Vanessa Ding, Ph.D. and Dr. Andre Choo, Ph.D, BTI, Singapore).

Research Category
Neuroscience
Quality【质量】
Identity Confirmation by Isotyping Test.

Isotyping Analysis: The identity of this monoclonal antibody is confirmed by isotyping test to be human IgG1 .
Physical form【外形】
Protein G purified
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Format: Purified
Other Notes【其他说明】
Concentration: Please refer to lot specific datasheet.
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
TAG-2A12, monoclonal
species reactivity
human
packaging【包装】
antibody small pack of 25 μg
technique(s)
flow cytometry: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype【同位素/亚型】
IgG1κ
NCBI accession no.【NCBI登记号】
NP_004896
UniProt accession no.【UniProt登记号】
P30041
shipped in【运输】
ambient
产品说明
Target description【目标描述】
~28 kDa observed; 25.03 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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