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Anti-PORCN Antibody, clone 15G12.1
产品别名
Anti-PORCN Antibody, clone 15G12.1
Probable protein-cysteine N-palmitoyltransferase porcupine, Protein MG61
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | PORCN is a multi-pass endoplasmic reticulum protein involved in the processing of wingless and other Wnt proteins that facilitate their secretion from Wnt-producing cells. Studies have shown mutations in the genes that encode for PORCN cause a pleiotropic X-linked dominant disorder, focal dermal hypolasia (FDH, also known as Goltz syndrome). Skeletal abnormalities such as syndactyly, ectordactyly, and brachydactyly, and some cases of osteopathia striata have also been attibuted to PORCN abnormalities. |
| Immunogen【免疫原】 | Linear peptide corresponding to human PORCN. |
| Application【应用】 | Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected PORCN in HeLa and A431 cells. Research Category Signaling Anti-PORCN Antibody, clone 15G12.1 is an antibody against PORCN for use in WB & IC. Research Sub Category Developmental Signaling |
| Quality【质量】 | Evaluated by Western Blot in mouse brain tissue lysate. Western Blot Analysis: A 1:1,000 dilution of this antibody detected PORCN in 10 µg of mouse brain tissue lysate. |
| Physical form【外形】 | Purified by Ion-Exchange Chromatography Format: Purified Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. |
| Analysis Note【分析说明】 | Control Mouse brain tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 15G12.1, monoclonal |
| species reactivity | mouse, rat, human |
| technique(s) | immunocytochemistry: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgMκ |
| NCBI accession no.【NCBI登记号】 | NP_073736 |
| UniProt accession no.【UniProt登记号】 | Q9H237 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~62 kDa observed. Calculated molecular weight of 52 kDa The actual MW should be observed at ~45-65 kDa Helical membrane protein migration on SDS-PAGE may not exactly correlate with the calculated molecular weights (PNAS, 2009, 106:1760-1765). |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
