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Anti-phospho-ITCH (pT222) Antibody

产品编号:4154804
规格:Chemicon®, from rabbit
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4154804100 μG7360
产品别名

Anti-phospho-ITCH (pT222) Antibody

Itchy homolog E3 ubiquitin protein ligase, AIP4, NAPP1

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
ITCH is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. ITCH regulates the transcriptional activity of several transcription factors including the hematopoietic transcription factor NF-E2, and may play an important role in the regulation of immune response. ITCH down-regulates Epstein-Barr virus LMP2A activity in B cell signaling, and also interacts with NOTCH1, OCLN, JUN, and JUNB. ITCH has a wide tissue distribution and is localized within the nucleus and cytoplasm. Two ITCH splice variants have been described; an approximately 103 kDa form as well as a truncated form (~98 kDa) lacking 42 amino acids in the N-terminal half of the protein. ITCH contains a MAP Kinase binding site and its activity is modulated by phosphorylation at multiple threonine residues by JNK1.
Specificity【特异性】
Human ITCH phosphorylated on threonine 222 (T222).
Immunogen【免疫原】
Synthetic peptide corresponding to a portion of human ITCH encompassing the phosphorylated Threonine at position 222 (PPPpTPRRP).
Application【应用】
Research Category
Protein Trafficking
Research Sub Category
Ubiquitin & Ubiquitin Metabolism
Western Blot: Recommended Dilution 1 - 5 μg/mL
Dot Blot
This Anti-phospho-ITCH (pT222) Antibody is validated for use in DB, WB for the detection of phospho-ITCH (pT222).
Physical form【外形】
Affinity purified immunoglobulin. Liquid in Tris-citrate/phosphate buffer, pH 7-8, containing 0.1% sodium azide.
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information【法律信息】
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
affinity purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
polyclonal
purified by【纯化方式】
affinity chromatography
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
dot blot: suitable
western blot: suitable
NCBI accession no.【NCBI登记号】
NM_031483.3
UniProt accession no.【UniProt登记号】
Q96J02
shipped in【运输】
wet ice
Gene Information
human ... ITCH(83737)
产品说明
Storage and Stability【储存及稳定性】
Maintain at 2-8°C for up to 12 months from date of receipt
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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