广州伟伯科技有限公司
您的位置:首页 > 产品中心 > Anti-PAR-3 Antibody, clone 8E8
产品搜索:

Anti-PAR-3 Antibody, clone 8E8

产品编号:4154774
规格:clone 8E8, from mouse
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4154774100 μG5010
产品别名

Anti-PAR-3 Antibody, clone 8E8

Proteinase-activated receptor 3, Coagulation factor II receptor-like 2, Thrombin receptor-like 2

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
PAR-3 (also known as Coagulation factor II receptor-like 2, Thrombin receptor-like 2 or F2RL2) is an adapter protein involved in asymmetrical cell division and cell polarization processes. It seems to play a central role in the formation of epithelial tight junctions. Its association with PARD6B may prevent the interaction of PAR-3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PAR-3 complex links GTP bound Rho small GTPases to atypical protein kinase C proteins. PAR-3 interacts with PARD6A and PARD6B. Isoform 2, but not at least isoform 3 interacts with PRKCZ. PAR-3 interacts with PRCKI. PAR-3 forms part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1. PAR-3 interacts with F11R/JAM1. Antibodies against PAR-3 are present in sera from patients with cutaneous T cell lymphomas.
Immunogen【免疫原】
KLH-conjugated linear peptide corresponding to human PAR-3.
Application【应用】
Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC. (Petrova, Y., et al. (2008). Centr Eur J Immunol. 33 (1):14-18.)

Activity Assay Analysis (platelet aggregation): A previous lot was used by an independent laboratory in platelet aggregation assay. (Petrova, Y., et al. (2008). Centr Eur J Immunol. 33 (1):14-18.)
Research Sub Category
Inflammation & Autoimmune Mechanisms
Anti-PAR-3 Antibody, clone 8E8 detects level of PAR-3 & has been published & validated for use in FC, EA.
Research Category
Infectious Diseases
Quality【质量】
Evaluated by Flow Cytometry in mouse platelets from washed whole blood (heparinized).

Flow Cytometry Analysis: 2 µg of this antibody detected PAR-3 in mouse platelets from washed whole blood (heparinized).
Linkage【联系】
Replaces: MABS174
Physical form【外形】
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified
Analysis Note【分析说明】
Control
Mouse platelets from washed whole blood (heparinized)
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
antibody form【抗体形式】
purified antibody
antibody product type
primary antibodies
clone【克隆】
8E8, monoclonal
species reactivity
mouse
species reactivity (predicted by homology)
human (based on 100% sequence homology)
technique(s)
activity assay: suitable
flow cytometry: suitable
isotype【同位素/亚型】
IgG2bκ
NCBI accession no.【NCBI登记号】
NP_004092
UniProt accession no.【UniProt登记号】
O00254
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
40 kDa calculated
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
广州伟伯科技有限公司 版权所有 CopyRight ©2006-2024, All Rights Reserved
工信部备案号:粤ICP备08114744号   Page Run Time: 0.0094