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Anti-Orexin-1 Receptor Antibody
产品别名
Anti-Orexin-1 Receptor Antibody
OX1R, Hypocretin Receptor 1
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | Several peptides associated with feeding behavior have been reported recently. Orexins (Orexin-A and Orexin-B) are a family of hypothalamic neuropeptides selectively expressed in the hypothalamus (Sakurai et al. 1998). Orexin-A and Orexin-B are derived from the same precursor (Prepro-orexin) by proteolytic cleavage. Prepro-orexin is an 130 aa peptide with a putative 33 aa secretory sequence, a hydrophobic core followed by residues with small polar side chains. The expression was detected in brain and to a small extent in testis (Sakurai et al. 1998). These neuropeptides bind and activate two closely related Orexin receptors--G protein coupled receptors (GPCRs) OX1R and OX2R. |
Specificity【特异性】 | Recognizes Rat and Human Orexin-1. |
Immunogen【免疫原】 | A 16 aa peptide near the N-terminus of rat OX1R and a 16 aa peptide near the C-terminus of human OX1R. |
Application【应用】 | Research Sub Category CNS Control of Metabolism Circadian Rhythm & Sleep Western blot: 1-10 μg/mL using Chemiluminescence technique. Protein runs at 45-48 kDa. ELISA: 1:10,000 -1:100,000 against 50-100 ng/wel immunogen peptide. Optimal working dilutions must be determined by end user. Research Category Neuroscience This Anti-Orexin-1 Receptor Antibody is validated for use in ELISA, WB for the detection of Orexin-1 Receptor. |
Physical form【外形】 | ImmunoAffinity Purified Affinity Purified immunoglobulin. Liquid in PBS with 0.1% BSA. |
Analysis Note【分析说明】 | Control Hypothalamus |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
Legal Information【法律信息】 | CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody form【抗体形式】 | affinity purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
purified by【纯化方式】 | affinity chromatography |
species reactivity | rat, mouse, human |
manufacturer/tradename | Chemicon® |
technique(s) | ELISA: suitable western blot: suitable |
NCBI accession no.【NCBI登记号】 | NM_001525.1 |
UniProt accession no.【UniProt登记号】 | O43613 |
shipped in【运输】 | dry ice |
Gene Information | human ... HCRTR1(3061) |
产品说明
Target description【目标描述】 | 45-48 kDa |
Storage and Stability【储存及稳定性】 | Maintain for 6 months at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 2 |