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Anti-Neuregulin-1 Antibody, clone D11

产品编号:4154680
规格:clone D11, from mouse
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4154680100 μG6190
产品别名

Anti-Neuregulin-1 Antibody, clone D11

neuregulin 1, sensory and motor neuron derived factor, neu differentiation factor, pro-neuregulin-1, membrane-bound isoform, heregulin, alpha (45kD, ERBB2 p185-activator), heregulin, alpha (45kD, ERBB2 p185-activator), glial growth factor

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
The group of Neuregulin-1 proteins are cell-cell signaling molecules and are ligands for receptor tyrosine kinases of the ErbB/HER subfamily. Type III NRG1 proteins (also referred to as CRD-NRG1 proteins) play a critical role in neural development, including myelination, motor and sensory neuron survival, and neuromuscular synapse development (Falls, 2003). Defects in animals lacking type III NRGs include retraction of nerve terminals from newly formed synapses, absence of Schwann cells from peripheral nerves, and loss of motor and sensory neurons (Wolpowitz et al., 2000). Available evidence indicates that most Type III NRG1 proteins are synthesized as transmembrane proteins with 2 TM domains, and that proteolytic processing produces a bioactive transmembrane form (NTFm) which serves as a juxtacrine signal (Wang, 2001; Falls, 2003).
Specificity【特异性】
This antibody recognizes Neuregulin-1 at the extracellular domain.
Immunogen【免疫原】
Epitope: Extracellular domain
His-tagged recombinant protein corresponding to mouse Neuregulin-1 at the extracellular domain.
Application【应用】
Detect Neuregulin-1 using this Anti-Neuregulin-1 Antibody, clone D11 validated for use in WB & IC.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience
Immunocytochemistry Analysis: A previous lot of this antibody was used successfully by an independent laboratory in IC. (Pirotte, D., et al.)
Quality【质量】
Evaluated by Western Blot in mouse brain microsomal tissue lysate.

Western Blot Analysis: 0.25 µg/mL of this antibody detected Neuregulin-1 on 10 µg of mouse brain microsomal tissue lysate.
Physical form【外形】
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G
Analysis Note【分析说明】
Control
Mouse brain microsomal tissue lysate
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
D11, monoclonal
species reactivity
mouse
technique(s)
immunocytochemistry: suitable
western blot: suitable
isotype【同位素/亚型】
IgG1κ
NCBI accession no.【NCBI登记号】
NP_848706
UniProt accession no.【UniProt登记号】
Q6DR99
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
~29 kDa observed. This target has been shown to undergo differential splicing during development into ~30 different isoforms.
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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