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Anti-Neuregulin-1 Antibody, clone D11
产品别名
Anti-Neuregulin-1 Antibody, clone D11
neuregulin 1, sensory and motor neuron derived factor, neu differentiation factor, pro-neuregulin-1, membrane-bound isoform, heregulin, alpha (45kD, ERBB2 p185-activator), heregulin, alpha (45kD, ERBB2 p185-activator), glial growth factor
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | The group of Neuregulin-1 proteins are cell-cell signaling molecules and are ligands for receptor tyrosine kinases of the ErbB/HER subfamily. Type III NRG1 proteins (also referred to as CRD-NRG1 proteins) play a critical role in neural development, including myelination, motor and sensory neuron survival, and neuromuscular synapse development (Falls, 2003). Defects in animals lacking type III NRGs include retraction of nerve terminals from newly formed synapses, absence of Schwann cells from peripheral nerves, and loss of motor and sensory neurons (Wolpowitz et al., 2000). Available evidence indicates that most Type III NRG1 proteins are synthesized as transmembrane proteins with 2 TM domains, and that proteolytic processing produces a bioactive transmembrane form (NTFm) which serves as a juxtacrine signal (Wang, 2001; Falls, 2003). |
Specificity【特异性】 | This antibody recognizes Neuregulin-1 at the extracellular domain. |
Immunogen【免疫原】 | Epitope: Extracellular domain His-tagged recombinant protein corresponding to mouse Neuregulin-1 at the extracellular domain. |
Application【应用】 | Detect Neuregulin-1 using this Anti-Neuregulin-1 Antibody, clone D11 validated for use in WB & IC. Research Category Neuroscience Research Sub Category Developmental Neuroscience Immunocytochemistry Analysis: A previous lot of this antibody was used successfully by an independent laboratory in IC. (Pirotte, D., et al.) |
Quality【质量】 | Evaluated by Western Blot in mouse brain microsomal tissue lysate. Western Blot Analysis: 0.25 µg/mL of this antibody detected Neuregulin-1 on 10 µg of mouse brain microsomal tissue lysate. |
Physical form【外形】 | Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Format: Purified Protein G |
Analysis Note【分析说明】 | Control Mouse brain microsomal tissue lysate |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | D11, monoclonal |
species reactivity | mouse |
technique(s) | immunocytochemistry: suitable western blot: suitable |
isotype【同位素/亚型】 | IgG1κ |
NCBI accession no.【NCBI登记号】 | NP_848706 |
UniProt accession no.【UniProt登记号】 | Q6DR99 |
shipped in【运输】 | wet ice |
产品说明
Target description【目标描述】 | ~29 kDa observed. This target has been shown to undergo differential splicing during development into ~30 different isoforms. |
Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |