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Anti-MBNL1 Antibody, clone 4A8
产品别名
Anti-MBNL1 Antibody, clone 4A8
muscleblind-like (Drosophila), muscleblind (Drosophila)-like, muscleblind-like protein 1, Triplet-expansion RNA-binding protein
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | Muscleblind 1 (MBNL1) is a member of the muscleblind family. MBNL1 is involved in pre-mRNA alternative splicing and acts as either splicing activator or repressor on specific pre-mRNA targets. This protein contains four C3H1-type zinc fingers and binds to expanded CUG repeat RNA. High expression of MBNL1 has been observed in cardiac and skeletal muscle as well as in differentiating myoblasts. MBNL1 is known to be involved in the pathogenesis of dystrophia myotonica type 1 (DM1). For those afflicted with this muscular disorder, MBNL1 is sequestered by DMPK RNAs that contain CUG triplet repeat expansions. |
Immunogen【免疫原】 | Full length recombinant protein corresponding to human MBNL1. |
Application【应用】 | Immunocytochemistry Analysis: 1:4 dilution from a representative lot detected MBNL1 in myotonic dystrophy cells. Data courtesy of Dr. Ian Holt, Wolfson Centre for Inherited Neuromuscular Disease. Anti-MBNL1 Antibody, clone 4A8 is a Mouse Monoclonal Antibody for detection of MBNL1 also known as muscleblind-like protein 1, Triplet-expansion RNA-binding protein & has been validated in WB, ICC. |
Quality【质量】 | Evaluated by Western Blot in HEK293 cell lysate. Western Blot Analysis: 1:10,000 dilution of this antibody detected MBNL1 on 10 µg of HEK293 cell lysate. |
Physical form【外形】 | Protein G Format: Purified |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | 4A8, monoclonal |
species reactivity | human |
technique(s) | immunocytochemistry: suitable western blot: suitable |
isotype【同位素/亚型】 | IgG1κ |
NCBI accession no.【NCBI登记号】 | NP_997176 |
UniProt accession no.【UniProt登记号】 | Q9NR56 |
shipped in【运输】 | wet ice |
Gene Information | human ... MBNL1(4154) |
产品说明
Target description【目标描述】 | ~39 kDa observed |
【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |