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Anti-LYVE1 Antibody
| 产品编号： | 4154584 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-LYVE1 Antibody
Cell surface retention sequence-binding protein 1, Extracellular link domain-containing protein 1, Hyaluronic acid receptor, cell surface retention sequence binding protein-1, extracellular link domain containing 1, extracellular link domain-containing 1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. LYVE1 may function in lymphatic hyaluronan transport. Additionally, LYVE1 has a role in tumor metastasis. |
| Specificity【特异性】 | Rat (90% sequence homology). This antibody recognizes LYVE1. |
| Immunogen【免疫原】 | Epitope: Unknown KLH-conjugated linear peptide corresponding to mouse LYVE1. |
| Application【应用】 | Research Sub Category Tumor Markers Not recommended to work in western blot using mouse liver lysate. Anti-LYVE1 Antibody is an antibody against LYVE1 for use in IH. Research Category Apoptosis & Cancer |
| Quality【质量】 | Evaluated by Immunohistochemistry in ovarian cancer tissue. Immunohistochemistry Analysis: 1:1,000 dilution of this antibody detected LYVE1 in ovarian cancer tissue. |
| Linkage【联系】 | Replaces: 07-538 |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control Ovarian cancer tissue |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | mouse (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable |
| isotype【同位素/亚型】 | IgG |
| NCBI accession no.【NCBI登记号】 | NP_444477 |
| UniProt accession no.【UniProt登记号】 | Q8BHC0 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... LYVE1(10894) |
产品说明
| Target description【目标描述】 | ~ 40 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
