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Anti-LRIG1 Antibody, clone 2D1.1

产品编号:4154575
规格:clone 2D1.1, from mouse
包装规格:25 μG,100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
415457525 μG1550
4154575100 μG5520
产品别名

Anti-LRIG1 Antibody, clone 2D1.1

Leucine-rich repeats and immunoglobulin-like domains protein 1, LIG-1

基本信息
eCl@ss
32160702
General description【一般描述】
Leucine-rich repeats and immunoglobulin-like domains protein 1 (UniProt: Q96JA1; also known as LIG-1) is encoded by the LRIG1 (also known as LIG1) gene (Gene ID: 26018) in human. LIG-1 is a widely expressed single-pass type I membrane protein that acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. LIG-1 contains 3 Ig-like C2-type (immunoglobulin-like) domains, 15 LRR (leucine-rich) repeats, 1 1 LRRCT domain, and 1LRRNT domain. The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding and this interaction is abolished only when these two domains are deleted. LIG-1 is highly expressed by intestinal stem cells and controls the size of the intestinal stem-cell niche by regulating the amplitude of growth-factor signaling. It is also reported to control stem-cell proliferation in epidermis. LIG-1 is reported to be expressed in a gradient with highest levels in intestinal stem cells and it is absent from Paneth cells. About one-third of all cells in the intestinal crypts are shown to express LIG-1. (Ref.: Wong VWY., et al. (2012). Nat. Cell Biol. 14(4); 401-408).
Specificity【特异性】
Clone 2D1.1 detects Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) in human. It targets an epitope within 134 amino acids from the C-terminal end.
Immunogen【免疫原】
GST/His-tagged recombinant fragment corresponding to 134 amino acids from the C-terminal end of human Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1).
Application【应用】
Anti-LRIG1 Antibody, clone 2D1.1, Cat. No. MABS1816, is a mouse monoclonal antibody that targets human Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) and has been tested for use in Western Blotting.
Research Category
Signaling
Quality【质量】
Evaluated by Western Blotting in LNCaP cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected LRIG1 in 10 µg of LNCaP cell lysate.
Physical form【外形】
Protein G purified
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Format: Purified
Other Notes【其他说明】
Concentration: Please refer to lot specific datasheet.
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
2D1.1, monoclonal
species reactivity
human
packaging【包装】
antibody small pack of 25 μg
technique(s)
western blot: suitable
isotype【同位素/亚型】
IgG1κ
NCBI accession no.【NCBI登记号】
NP_056356
UniProt accession no.【UniProt登记号】
Q96JA1
shipped in【运输】
ambient
Gene Information
human ... LRIG1(26018)
产品说明
Target description【目标描述】
~150 kDa observed; 119.11 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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