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Anti-LAMP-2 Antibody, clone ABL-93
产品别名
Anti-LAMP-2 Antibody, clone ABL-93
lysosomal-associated membrane protein 2, CD107 antigen-like family member B, CD107b antigen
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | Lysosome-associated membrane protein 2 (LAMP-2) is a highly glycosolated protein belonging to the lysosome-associated membrane protein family. This group pf proteins composes a significant portion of the lysosomal membrane and are considered crucial mediators for cellular adhesion by interacting with carbohydrate receptors. LAMP-2 is a profuse and critical component of the lysosomal membrane as it has been implicated in playing a role in lysosomal biogenesis. It also appears to be involved in later stages of phagocytosis and autophagy, where it may act to protect the lysosomal membrane from being digested, assist in signal transduction, moderate levels of acidity within the lysosomal environment, and participate in adhesion. Mutations in LAMP-2 expression have been associated with lysosomal storage diseases or LSDs, along with Danon disease, an X-linked disorder characterized by skeletal myopathy, mental retardation, and hypertrophic cardiomyopathy. |
Specificity【特异性】 | This antibody recognizes LAMP-2. |
Immunogen【免疫原】 | Purified glycoproteins from NIH/3T3 cells, corresponding to mouse LAMP-2. |
Application【应用】 | Research Sub Category Apoptosis - Additional Immunoprecipitation Analysis: This antibody has been shown to immunoprecipitate LAMP-2 in HaNIH cells, (Chen, 1985). Immunofluorescence Analysis: This antibody has been shown to detect LAMP-2 in mouse brain, (Ferguson, 2009). Anti-LAMP-2 Antibody, clone ABL-93 is an antibody against LAMP-2 for use in WB, IP & IF. Research Category Apoptosis & Cancer |
Quality【质量】 | Evaluated by Western Blot in NIH/3T3 cell lysate. Western Blot Analysis: 1 µg/mL of this antibody detected LAMP-2 in 10 µg of NIH/3T3 cell lysate. |
Physical form【外形】 | Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Format: Purified Protein G |
Analysis Note【分析说明】 | Control NIH/3T3 cell lysate |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | rat |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | ABL-93, monoclonal |
species reactivity | mouse |
technique(s) | immunofluorescence: suitable immunoprecipitation (IP): suitable western blot: suitable |
isotype【同位素/亚型】 | IgG2aκ |
NCBI accession no.【NCBI登记号】 | NP_001017959 |
UniProt accession no.【UniProt登记号】 | P17047 |
shipped in【运输】 | wet ice |
产品说明
Target description【目标描述】 | ~ 80 kDa observed MW. The calculated MW is 45 kDa LAMP-2 is heavily glycosoated and has been routinely observed at MW′s of 80-120 kDa based on publication data, (Chen, 1985; Ferguson, 2009). |
Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |