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Anti-Glutamate Receptor Delta 1/2 Antibody
| 产品编号： | 4154436 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Glutamate Receptor Delta 1/2 Antibody
GluR delta-1, glutamate receptor, ionotropic, delta 1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | The majority of rapid excitatory transmission in the nervous system is mediated by glutamate-activated ion channels. Ionotropic glutamate receptors have been subdivided pharmacologically into AMPA (cx-amino-3-hydroxy-5methyl-Cisoxazole propionic acid), KA (kainate), and NMDA subtypes (Monaghan et al., 1989). These receptors have been implicated in a number of physiological and pathological processes. During development glutamate receptors are involved in neuronal differentiation, migration, and activity-dependent synapse formation (Balazs et al., 1989; Brewer, 1989; Komoru and Rakic, 1993). In mature neurons, long-term potentiation and long-term depression require ionotropic glutamate receptors. Glutamate-gated ion channels also play a central role in mediating the excitotoxic effects of glutamate (Olney, 1990). Pathophysiological processes thought to involve glutamate excitotoxicity and neurodegeneration include epilepsy stroke, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. |
| Specificity【特异性】 | Reacts weakly with mouse. May react with Primate based on sequence homology. Reactivity with other species has not been tested. Cat. # AB2285 reacts with the C-Terminus of Glutamate Receptor Delta 1/2. |
| Immunogen【免疫原】 | Epitope: C-Terminus, Cytoplasmic Synthetic linear peptide to the C-Terminus, conjugated to BSA. |
| Application【应用】 | Anti-Glutamate Receptor Delta 1/2 Antibody detects level of Glutamate Receptor Delta 1/2 & has been published & validated for use in WB. Research Category Neuroscience Western Blotting: Human Cerebellum Lysate. Research Sub Category Neurotransmitters & Receptors |
| Quality【质量】 | Western Blotting: 1:5,000 dilution from a previous lot detected Glutamate Receptor Delta 1/2 on 10 µg of rat or human cerebellum lysate. |
| Physical form【外形】 | Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. Antigen Affinity Purified |
| Analysis Note【分析说明】 | Control Rat cerebellum tissue lysate and human cerebellum tissue lysate. |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | rat, primate, human, mouse |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NM_017551.2 |
| UniProt accession no.【UniProt登记号】 | Q9ULK0 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... GRID1(2894) |
产品说明
| Target description【目标描述】 | ~114 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8ºC from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
