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Anti-GABA(A) receptor subunit gamma-2 Antibody
产品别名
Anti-GABA(A) receptor subunit gamma-2 Antibody
gamma-aminobutyric acid (GABA) A receptor, gamma 2, gamma-aminobutyric acid A receptor, gamma 2, GABA(A) receptor subunit gamma-2
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | GABA(A) receptor subunit gamma-2 is a protein belonging to a subclass of GABA receptors known as GABA (A). GABA (A) receptors are pentameric chloride channels composed of subunits belonging to different homology classes, i.e. α, β, γ, δ, θ, ε, π, and act as receptors for GABA, a crucial inhibitory neurotransmitter localized within the brain. GABA (A) gamma 2 subunit consists of 5 cysteine residues and carries the binding site for benzodiazepine. The subunit functions to promote receptor maintenance and clustering at the synapse, interacts with GABA receptor associated proteins such as GODZ and GABAWRAP, affects GABA (A) receptor conductance and kinetics, and is a contributing component to receptors participating in both phasic and tonic inhibition. Several mutations in the GABA(A) receptor subunit gamma-2 expression have been linked to epileptic syndromes that result in fibrile seizures. |
Specificity【特异性】 | This antibody recognizes GABA(A) receptor subunit gamma-2. |
Immunogen【免疫原】 | GST-tagged recombinant protein corresponding to rat GABA(A) receptor subunit gamma-2. |
Application【应用】 | Research Category Neuroscience Research Sub Category Neurotransmitters & Receptors This Anti-GABA(A) receptor subunit gamma-2 Antibody is validated for use in WB for the detection of GABA(A) receptor subunit gamma-2. |
Quality【质量】 | Evaluated by Western Blot in PC12 cell lysate. Western Blot Analysis: 1:1,000 dilution of this antibody detected GABA(A) receptor subunit gamma-2 on 10 µg of PC12 cell lysate. |
Physical form【外形】 | Unpurified Rabbit polyclonal serum containing 0.05% sodium azide. |
Analysis Note【分析说明】 | Control PC12 cell lysate |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody form【抗体形式】 | serum |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
species reactivity | human, rat |
technique(s) | western blot: suitable |
NCBI accession no.【NCBI登记号】 | NP_899156 |
UniProt accession no.【UniProt登记号】 | P18508 |
shipped in【运输】 | wet ice |
Gene Information | human ... GABRG2(2566) |
产品说明
Target description【目标描述】 | ~60 kDa observed |
Storage and Stability【储存及稳定性】 | Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |