Anti-Cathelicidin/FALL-39/LL-37 Antibody, clone 8C10.1

32160702

NA.41

Cathelicidin antimicrobial peptide (UniProt P49913; also known as 18 kDa cationic antimicrobial protein, CAP-18, hCAP-18) is encoded by the CAMP (also known as CAP18, FALL39, LL37) gene (ORF HSD26; Gene ID 820) in human. The human cathelicidin antimicrobial protein 18 (hCAP-18) is initially translated as a precursor molecule with a signal peptide (a.a. 1-30) and a propeptide (a.a. 31-131) sequence, the removal of which yields the mature hCAP-18 (a.a. a.a. 132-173). During the inflammatory response, hCAP-18 is proteolytically cleaved into the FALL-39 (a.a 132-170), which is further processed to yield the antimicrobial protein LL-37 (CAP-37; a.a. 134-170). Neutrophils store preformed hCAP-18 within specific granules and release it into inflamed tissue as a result of granule exocytosis. Once released, hCAP-18 is activated by proteinase-3-mediated cleavage, a component of neutrophil primary granules. In addition to its microbicidal and LPS-sequestering activity, LL-37 is also involved in the regulation of innate and humoral immune responses, wound healing, and tissue repair.

Clone 8C10.1 targets a C-terminal epitope present in the prepro- (a.a. 1-173) and pro- (a.a. 31-173) forms of hCAP-18, as well as the processed antibacterial peptides FALL-39 (a.a 132-170) and LL-37 (a.a. 134-170), but not the preprodomain (a.a. 1-131) or prodomain (a.a. 31-131) fragment.

KLH-conjugated linear peptide corresponding to the C-terminal sequence of human Cathelicidin/FALL-39/LL-37.
Epitope: C-terminal.

Research Sub Category
Inflammation & Autoimmune Mechanisms
Anti-Cathelicidin Antibody, clone 8C10.1 is an antibody against Cathelicidin/FALL-39/LL-37 for use in Immunohistochemistry.
Research Category
Signaling
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Cathelicidin/FALL-39/LL-37 immunoreactivity in human spleen tissue sections.

Evaluated by Immunohistochemistry in human bone marrow tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Cathelicidin/FALL-39/LL-37 immunoreactivity in human bone marrow tissue sections.

Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

Concentration: Please refer to lot specific datasheet.

100

mouse

purified antibody

primary antibodies

8C10.1, monoclonal

human

immunohistochemistry: suitable

IgG1κ

NP_004336

P49913

wet ice

human ... CAMP(820)

19.30 kDa (prepro-hCAP-18), 16.02 kDa (pro-hCAP-18), 4.712 kDa (FALL-39; a.a. 132-170) and 4.493 kDa (LL-37; a.a. 134-170) calculated.

Stable for 1 year at 2-8°C from date of receipt.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids

WGK 1