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Anti-BDCA-2 Antibody, clone 10E6.1
产品别名
Anti-BDCA-2 Antibody, clone 10E6.1
C-type lectin domain family 4 member C, Blood dendritic cell antigen 2, BDCA-2, C-type lectin superfamily member 7, Dendritic lectin, CD303
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Blood dendritic cell antigen 2 (BDCA-2;CD303) is a type II C-type lectin that is expressed on plasmacytoid dendritic cells (PDC), a subset of immature dendritic cells found in lymphoid and nonlymphoid tissues. BDCA-2 is critically involved in both adaptive and innate immune responses. It is involved in the recognition and internalization of pathogens, but inhibits TLR6 signaling and INF-1 production, in PDC cells, possibly through signaling of the BCR-like signalosome. PDC signaling has been linked to multiple inflammatory diseases such as granulomatous lymphadenitis. |
| Immunogen【免疫原】 | GST-tagged recombinant protein corresponding to human BDCA-2. |
| Application【应用】 | Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected BDCA-2 in human tonsil tissue. Research Sub Category Immunoglobulins & Immunology Detect BDCA-2 using this Anti-BDCA-2 Antibody, clone 10E6.1 validated for use in Western Blotting & IHC. Research Category Inflammation & Immunology |
| Quality【质量】 | Evaluated by Western Blot in recombinant BDCA-2 protein. Western Blot Analysis: 1 µg/mL of this antibody detected BDCA-2 on 10 µg of recombinant BDCA-2 protein. |
| Physical form【外形】 | Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Format: Purified Protein G Purified |
| Analysis Note【分析说明】 | Control Recombinant BDCA-2 protein |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 10E6.1, monoclonal |
| species reactivity | human |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | NP_569708 |
| UniProt accession no.【UniProt登记号】 | Q8WTT0 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~33 kDa observed. Uncharacterized bands appear at ~25 and ~31 kDa in some lysates. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
