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Anti-AMACR Antibody

产品编号:4154125
规格:Chemicon®, from rabbit
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4154125100 μG7740
产品别名

Anti-AMACR Antibody

a-methylacyl-CoA racemase, P504S

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Prostate-specific antigen (PSA) screening for prostate cancer is now widespread in the United States among men of all ages. However PSA has limited specificity because benign disease, including prostatic enlargement and inflammation, can increase PSA levels. Thus, a more specific prostate cancer markers is needed. One such potential marker is AMACR, an enzyme that is involved in peroxisomal beta-oxidation of dietary branched-chain fatty acids. Recent studies have shown that, compared with expression in normal or benign prostate epithelium, AMACR is consistently overexpressed in prostate cancer epithelium, making it a specific marker for cancer cells within the prostate gland. Furthermore, overexpression of AMACR may increase the risk of prostate cancer because its expression is increased in premalignant lesions (prostatic intraepithelial neoplasia).
Specificity【特异性】
Recognizes human AMACR (alpha-methylacyl-CoA racemase).
Immunogen【免疫原】
Synthetic human AMACR peptide.
Application【应用】
Western blot: 1:500

Immunohistochemistry: 1:100 in an ABC method. An incubation period of 30 minutes at room temperature is suggested. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining.

Optimal working dilutions must be determined by end user.
Detect AMACR using this Anti-AMACR Antibody validated for use in WB, IH(P).
Physical form【外形】
Peptide affinity purified antibody. Liquid in PBS, with 0.02% sodium azide as a preservative.
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information【法律信息】
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
300
biological source【生物来源】
rabbit
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
purified by【纯化方式】
affinity chromatography
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.【NCBI登记号】
NM_014324.4
NM_203382.1
UniProt accession no.【UniProt登记号】
Q9UHK6
shipped in【运输】
wet ice
Gene Information
human ... AMACR(23600)
产品说明
Storage and Stability【储存及稳定性】
Maintain at 2-8ºC in undiluted aliquots for 3 months or at -20°C for up to one year from date of receipt. Avoid repeated freeze-thaw cycles.
【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 2
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