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Bryostatin 1-CAS 83314-01-6-Calbiochem
| 产品编号： | 4152265 |
| 规格： | A macrocyclic lactone with antitumor properties. |
| CAS NO： | 83314-01-6 |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4152265 | 10 μG | 2470 |
产品别名
83314-01-6
Bryostatin 1-CAS 83314-01-6-Calbiochem
Bryo 1, PKC Activator VII, PKC Activator VI
基本信息
| Empirical Formula【经验(实验)分子式】 | C47H68O17 |
| Molecular weight | 905.03 |
| MDL number | MFCD00893832 |
| General description【一般描述】 | A macrocyclic lactone that exhibits anti-tumor properties. Potently activates protein kinase C and exhibits high binding affinity (Ki = 1.35 nM). Effectively translocates protein kinase C (PKC) isozymes α, β, and ε and induces a biphasic, concentration-dependent, down-regulation of PKC δ. Reported to compete with phorbol esters in binding to PKC. Stimulates protein kinase D (PKD) activity in a biphasic, PKC-dependent manner in intact cells. Also activates Ras in Jurkat T cells and in rat2 cells. A macrocyclic lactone with antitumor properties. Potently activates protein kinase C and exhibits a high binding affinity (Ki = 1.35 nM). Effectively translocates and down-regulates PKC isozymes α, δ, and ε. Induces a biphasic activation of PKD through a PKC-dependent pathway in intact cells. Also shown to activate Ras in Jurkat T cells and in rat2 cells. |
| Biochem/physiol Actions【生化/生理作用】 | Target Ki: 1.35 nM for protein kinase C Product does not compete with ATP. Reversible: no Primary Target Protein kinase C Cell permeable: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Clamp, A., and Jayson, G. 2002. Anticancer Drugs13, 673. Lorenzo, P.S., et al. 1999. Cancer Res.59, 6137. Wang, Q.J., et al. 1999. J. Biol. Chem.274, 37233. Wender, P.A., et al. 1998. Proc. Natl. Acad. Sci. USA95, 6624. Matthews, S.A., et al. 1997. J. Biol. Chem.272, 20245. Szallasi, Z., et al. 1994. Mol. Pharmacol.46, 840. Berkow, R.L., and Kratt, A.S. 1985. Biochem. Biophys. Res. Commun.3, 1109. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | film solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white to colorless |
| solubility【溶解性】 | DMSO: 25 mg/mL ethanol: 25 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35?,36?,37?,38?,43+,46+,47-/m1/s1 |
| InChI key | MJQUEDHRCUIRLF-BXOMOELISA-N |
| packaging【包装】 | 10 μg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
