Anti-Prion Protein Antibody, NT, a.a. 78-97

32160702

Specific for human prion protein (PrP). This antibody immunolabels amyloid plaques in formalin-fixed paraffin sections from Creutzfeld-Jakob Disease (CJD) brain.The prion protein is a large membrane protein that occurs normally in neurons of the human brain and is thought to be involved in synaptic transmission. In prion diseases, such as CJD, Gerstmann-Straussler-Scheinker syndrome (GSS), Fatal Familial Insomnia (FFI), Alpers Syndrome and Kuru, the normal cellular form of this protein (PrPc) is transformed into an altered protein when it comes into contact with an infectious prion protein (PrPsc) from another host. This altered PrPsc accumulates in cytoplasmic vesicles of diseased individuals forming lesions, vacuoles and amyloid deposits.

Synthetic peptide that corresponds to amino acids 79-97 of the N-terminus of the human PrP27-30.
Epitope: N-terminus, a.a. 78-97

Research Category
Neuroscience
Anti-Prion Protein Antibody, N-terminus, a.a. 78-97 detects level of Prion Protein & has been published & validated for use in ELISA, WB, IH(P).
Immunohistochemistry: >1:200 on paraffin embedded, formalin fixed human brain.

Western blots: >1:2,000

ELISA: >1:35,000

Optimal working dilutions must be determined by the end user.
Research Sub Category
Neurodegenerative Diseases

Goat serum. Liquid containing 0.01% thimerosal

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

100

goat

serum

primary antibodies

polyclonal

human

Chemicon^®

ELISA: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

NM_000311.3
NM_001080121.1
NM_001080122.1
NM_001080123.1
NM_183079.2

P04156

dry ice

human ... PRNP(5621)

Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.