MCI-186-CAS 89-25-8-Calbiochem

C₁₀H₁₀N₂O

174.20

MFCD00003138

A free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC₅₀ = 15 µM). Inhibits mitochondrial permeability transition pore.
A free radical scavenger and antioxidant that reduces post-ischemie brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC₅₀ = 15 µM). Inhibits mitochondrial permeability transition pore.

Product does not compete with ATP.
Reversible: no
Target IC₅₀: 15 µM inhibiting iron-dependent peroxidation in rat brain homogenates
Cell permeable: no
Primary Target
A free radical scavenger and antioxidant

Toxicity: Harmful (C)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Katare, R. G., et al. 2003. Am. J. Physiol.285, H2171.
Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921.
Yamamoto, Y., et al. 1996. Redox. Report 2, 333.
Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597.
Nishi, H., et al. 1989. Stroke 20, 1236.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

cream

DMSO: 100 mg/mL

ambient

2-8℃

1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3

QELUYTUMUWHWMC-UHFFFAOYSA-N

500 mg in Plastic ampoule
Packaged under inert gas

GHS07

Warning

H302 - H319

P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313

Acute Tox. 4 Oral - Eye Irrit. 2

11 - Combustible Solids

WGK 1