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InSolution TAPI-1-Calbiochem

产品编号:4145205
规格:InSolution TAPI-1, CAS 171235-71-5, is a 10 mM solution of TAPI-1 in DMSO. A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE.
包装规格:500 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4145205500 μG3120
基本信息
Empirical Formula【经验(实验)分子式】
C26H37N5O5
Molecular weight
499.60
General description【一般描述】
A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-α convertase; ADAM17). However, TAPI-1 is more stable in serum than TAPI-0. TAPI-1 Blocks the shedding of several cell surface proteins such as TNF-α, IL-6 receptor, and p60 and p80 TNF receptors. Inhibits constitutive (IC50 = 8.09 μM) and muscarinic receptor-stimulated (IC50 = 3.61 μM) sAPPa release in HEK-293 cells expressing muscarinic receptors. Also blocks the TACE-dependent constitutive release of co-transfected APP(695) (IC50 = 920 nM).
Biochem/physiol Actions【生化/生理作用】
Target IC50: 8.09 µM, 3.61 µM in blocking constitutive and muscarinic receptor-stimulated sAAPα release in HEK 293 cells expressing M3 muscarinic receptors
Primary Target
MMPs and TACE
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Warning【警告】
Toxicity: Irritant (B)
Physical form【外形】
A 10 mM (500 µg/100 µl) solution of TAPI-1 (Cat. No. 579051) in DMSO.
Reconstitution【重悬】
Following initial thaw, aliquot and freeze (-20°C).
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥97% (HPLC)
form【形式】
liquid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
desiccated (hygroscopic)
protect from light
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
packaging【包装】
500 μg in Plastic ampoule
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)【闪点(F)】
188.6 °F - (Dimethylsulfoxide)
Flash Point(C)【闪点(C)】
87 ℃ - (Dimethylsulfoxide)
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