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InSolution Staurosporine, Streptomyces sp.

产品编号:4145203
规格:InSolution Staurosporine, Streptomyces sp. CAS 62996-74-1, is provided as a 1 mM (100 μg/214 μl) solution of Staurosporine (Cat. No. 569397) in DMSO
CAS NO:62996-74-1
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
4145203100 μG2570
产品别名

62996-74-1

InSolution Staurosporine, Streptomyces sp.

PKA Inhibitor II, MLCK Inhibitor I

基本信息
Empirical Formula【经验(实验)分子式】
C28H26N4O3
Molecular weight
466.53
MDL number
MFCD00077402
General description【一般描述】
A potent, cell-permeable broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint.
Biochem/physiol Actions【生化/生理作用】
Cell permeable: yes
Product competes with ATP.
Target IC50: 7 nM, 20 nM, 1.3 nM, 700 pM, 8.5 nM, against protein kinase A , CaM kinase, myosin light chain kinase, protein kinase C, and protein kinase G, respectively
Reversible: yes
Primary Target
PKA
Warning【警告】
Toxicity: Irritant (B)
Physical form【外形】
A 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 569397) in DMSO.
Reconstitution【重悬】
Following initial thaw, aliquot, purge with inert gas, and freeze (-70°C).
Other Notes【其他说明】
Couldwell, W.T., et al. 1994. FEBS Lett.345, 43.
Nishimura, H. and Simpson, I.A. 1994. Biochem. J.302, 271.
Bruno, S., et al. 1992. Cancer Res.52, 470.
Kiss, Z. and Deli, E. 1992. Biochem. J.288, 853.
Vitale, M.L., et al. 1992. Neuroscience51, 463.
Hoffman, R. and Newland, E.S. 1991. Cancer Chemotherap. Pharmacol.28, 102.
Oka, S., et al. 1986. Agric. Biol. Chem.50, 2723.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥97% (HPLC)
form【形式】
liquid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
protect from light
shipped in【运输】
wet ice
storage temp.【储存温度】
−70℃
InChI
1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
InChI key
HKSZLNNOFSGOKW-FYTWVXJKSA-N
packaging【包装】
100 μg in Plastic ampoule
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)【闪点(F)】
188.6 °F - (Dimethylsulfoxide)
Flash Point(C)【闪点(C)】
87 ℃ - (Dimethylsulfoxide)
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