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InSolution Smoothened 激动剂,SAG-Calbiochem
InSolution Smoothened Agonist, SAG-Calbiochem
产品编号: | 4145202 |
规格: | InSolution |
包装规格: | 500 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
InSolution
InSolution Smoothened Agonist, SAG-Calbiochem
SAG1.3 in Solution
SAG 1.3 in Solution
基本信息
Empirical Formula【经验(实验)分子式】 | C28H28ClN3OS · 2HCl · xH2O |
Molecular weight | 562.98 (anhydrous basis) |
General description【一般描述】 | A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Hedgehog pathway activation (EC50 ∼3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations. |
Warning【警告】 | Toxicity: Standard Handling (A) |
Physical form【外形】 | A 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566660) in H₂O. |
Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-20°C). |
Other Notes【其他说明】 | Meloni, A.R., et al. 2006. Mol. Cell. Biol.26, 7750. Chen, W., et al. 2004. Science306, 2257. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA99, 14071. Frank-Kamenetsky, M., et al. 2002. J. Biol.1, 10. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥95% (HPLC) |
form【形式】 | liquid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
packaging【包装】 | 500 μg in Plastic ampoule Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 2 |