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InSolution OM99-2-CAS 314266-76-7-Calbiochem
产品编号: | 4145196 |
规格: | An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2. |
CAS NO: | 314266-76-7 |
包装规格: | 250 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4145196 | 250 μG | 9000 |
产品别名
314266-76-7
InSolution OM99-2-CAS 314266-76-7-Calbiochem
EVNLΨAAEF
基本信息
Empirical Formula【经验(实验)分子式】 | C41H64N8O14 |
Molecular weight | 892.99 |
MDL number | MFCD03452932 |
General description【一般描述】 | An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2 (Ki = 1.6 nM, recombinant memapsin 2; Ki = 9.58 nM, recombinant pro-memapsin 2). Also inhibits cathepsin D (Ki = 48 nM). This aspartyl protease inhibitor is designed from the template of the β-secretase site of Swedish β-amyloid precursor protein (APP) with Asp to Ala replacement; also includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala. A peptidomimetic, highly potent, tight-binding transition-state analog inhibitor of human brain β-secretase (Ki = 1.6 nM, recombinant memapsin-2; Ki = 9.58 nM, recombinant pro-memapsin 2). Designed from the template of the β-secretase site of Swedish β-amyloid precursor protein (APP) with Asp to Ala replacement. Includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala. Also reported to inhibit cathepsin D at higher levels (Ki = 48 nM). |
Biochem/physiol Actions【生化/生理作用】 | Product does not compete with ATP. Target Ki: 1.6 nM against recombinant memapsin 2; 9.58 nM against recombinant pro-memapsin 2; 48 nM against cathepsin D Primary Target human brain memapsin 2 Reversible: no Cell permeable: no |
Warning【警告】 | Toxicity: Standard Handling (A) |
Sequence【序列】 | Glu-Val-Asn-Leu-Ψ-Ala-Ala-Glu-Phe [Ψ denotes replacement of CONH by (S)-CH(OH)CH₂] |
Physical form【外形】 | A 1 mM (250µg in 280 µl) solution in DMSO. Supplied as a trifluoroacetate salt. |
Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions. |
Other Notes【其他说明】 | Ghosh, A.K., et al. 2001. J. Med. Chem.44, 2865. Turner III, R.T., et al. 2001. Biochemistry40, 10001. Ghosh, A.K., et al. 2000. J. Am. Chem. Soc.122, 3522. Hong, L., et al. 2000. Science290,150. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥90% (HPLC) |
form【形式】 | liquid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze desiccated protect from light |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | −20℃ |
InChI | 1S/C39H60N8O14/c1-18(2)12-24(43-36(57)25(16-29(41)49)45-38(59)32(19(3)4)47-35(56)23(40)15-30(50)51)28(48)13-20(5)33(54)42-21(6)34(55)44-26(17-31(52)53)37(58)46-27(39(60)61)14-22-10-8-7-9-11-22/h7-11,18-21,23-28,32,48H,12-17,40H2,1-6H3,(H2,41,49)(H,42,54)(H,43,57)(H,44,55)(H,45,59)(H,46,58)(H,47,56)(H,50,51)(H,52,53)(H,60,61)/t20-,21+,23+,24+,25+,26+,27+,28+,32+/m1/s1 |
InChI key | JCNFYXCBSRPSLY-QYTLZHMISA-N |
packaging【包装】 | 250 μg in Plastic ampoule Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |
Flash Point(F)【闪点(F)】 | 188.6 °F - (Dimethylsulfoxide) |
Flash Point(C)【闪点(C)】 | 87 ℃ - (Dimethylsulfoxide) |