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InSolution OM99-2-CAS 314266-76-7-Calbiochem

产品编号:4145196
规格:An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2.
CAS NO:314266-76-7
包装规格:250 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
4145196250 μG9000
产品别名

314266-76-7

InSolution OM99-2-CAS 314266-76-7-Calbiochem

EVNLΨAAEF

基本信息
Empirical Formula【经验(实验)分子式】
C41H64N8O14
Molecular weight
892.99
MDL number
MFCD03452932
General description【一般描述】
An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2 (Ki = 1.6 nM, recombinant memapsin 2; Ki = 9.58 nM, recombinant pro-memapsin 2). Also inhibits cathepsin D (Ki = 48 nM). This aspartyl protease inhibitor is designed from the template of the β-secretase site of Swedish β-amyloid precursor protein (APP) with Asp to Ala replacement; also includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala.
A peptidomimetic, highly potent, tight-binding transition-state analog inhibitor of human brain β-secretase (Ki = 1.6 nM, recombinant memapsin-2; Ki = 9.58 nM, recombinant pro-memapsin 2). Designed from the template of the β-secretase site of Swedish β-amyloid precursor protein (APP) with Asp to Ala replacement. Includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala. Also reported to inhibit cathepsin D at higher levels (Ki = 48 nM).
Biochem/physiol Actions【生化/生理作用】
Product does not compete with ATP.
Target Ki: 1.6 nM against recombinant memapsin 2; 9.58 nM against recombinant pro-memapsin 2; 48 nM against cathepsin D
Primary Target
human brain memapsin 2
Reversible: no
Cell permeable: no
Warning【警告】
Toxicity: Standard Handling (A)
Sequence【序列】
Glu-Val-Asn-Leu-Ψ-Ala-Ala-Glu-Phe [Ψ denotes replacement of CONH by (S)-CH(OH)CH₂]
Physical form【外形】
A 1 mM (250µg in 280 µl) solution in DMSO. Supplied as a trifluoroacetate salt.
Reconstitution【重悬】
Following initial thaw, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
Other Notes【其他说明】
Ghosh, A.K., et al. 2001. J. Med. Chem.44, 2865.
Turner III, R.T., et al. 2001. Biochemistry40, 10001.
Ghosh, A.K., et al. 2000. J. Am. Chem. Soc.122, 3522.
Hong, L., et al. 2000. Science290,150.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥90% (HPLC)
form【形式】
liquid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
desiccated
protect from light
shipped in【运输】
ambient
storage temp.【储存温度】
−20℃
InChI
1S/C39H60N8O14/c1-18(2)12-24(43-36(57)25(16-29(41)49)45-38(59)32(19(3)4)47-35(56)23(40)15-30(50)51)28(48)13-20(5)33(54)42-21(6)34(55)44-26(17-31(52)53)37(58)46-27(39(60)61)14-22-10-8-7-9-11-22/h7-11,18-21,23-28,32,48H,12-17,40H2,1-6H3,(H2,41,49)(H,42,54)(H,43,57)(H,44,55)(H,45,59)(H,46,58)(H,47,56)(H,50,51)(H,52,53)(H,60,61)/t20-,21+,23+,24+,25+,26+,27+,28+,32+/m1/s1
InChI key
JCNFYXCBSRPSLY-QYTLZHMISA-N
packaging【包装】
250 μg in Plastic ampoule
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)【闪点(F)】
188.6 °F - (Dimethylsulfoxide)
Flash Point(C)【闪点(C)】
87 ℃ - (Dimethylsulfoxide)
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