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InSolution K-252a, Nocardiopsis sp.-CAS 97161-97-2-Calbiochem
产品别名
97161-97-2
InSolution K-252a, Nocardiopsis sp.-CAS 97161-97-2-Calbiochem
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H21N3O5 |
| Molecular weight | 467.47 |
| General description【一般描述】 | A cell-permeable protein kinase inhibitor that inhibits CaM kinase II (Ki = 1.8 nM), myosin light chain kinase (Ki = 17 nM), protein kinase A (Ki = 18 nM), protein kinase C (Ki = 25 nM), and protein kinase G (Ki = 20 nM). Also acts as a potent inhibitor (IC50 = 3 nM) of the tyrosine protein kinase activity of the NGF receptor gp 140trk, the product of the trk protooncogene. Also inhibits the kinase activity of its transforming alleles, the trk oncogenes, and of the related neurotrophin receptors gp 145trkB and gp 145trkC. Induces apoptosis and cell cycle arrest by inhibiting Cdc2 and Cdc25c. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target CaM kinase II Target Ki: 1.8 nM, 20 nM, 18 nM, 25 nM, 20 nM, 3 nM, against CaM kinase II, myosin light chain kinase, protein kinase A, protein kinase C, protein kinase G, NGF receptor gp140trk, respectively Product competes with ATP. Reversible: yes |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 1 mM (100 µg/214 µl) solution of K-252a (Cat. No. 420298) in DMSO. |
| Reconstitution【重悬】 | Following initial thaw aliquot and freeze at (-20°C). Store under an inert atmosphere. |
| Other Notes【其他说明】 | Chin, L.S., et al. 1999. Cancer Invest.17, 391. Nakanishi, N., et al. 1995. FEBS Lett.368, 411. Ross, A.H., et al. 1995. J. Neurochem.65, 2748. Mizuno, K., et al. 1993. FEBS Lett.330, 114. Pawlowska, Z., et al. 1993. J. Neurochem.60, 678. Tapley, P., et al. 1992. Oncogene7, 371. Simpson, D.L., et al. 1991. J. Neurosci. Res.28, 486. Hashimoto, S. 1988. J. Cell Biol.107, 1531. Koizuma, S., et al. 1988. J. Neurosci.8, 715. Kase, H., et al. 1987. Biochem. Biophys. Res. Commun.142, 436. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31) |
| InChI key | KOZFSFOOLUUIGY-UHFFFAOYSA-N |
| packaging【包装】 | 100 μg in Plastic ampoule Packaged under inert gas |
