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InSolution JAK Inhibitor I-CAS 457081-03-7-Calbiochem
产品编号: | 4145194 |
规格: | The InSolution |
CAS NO: | 457081-03-7 |
包装规格: | 500 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4145194 | 500 μG | 2150 |
产品别名
457081-03-7
InSolution JAK Inhibitor I-CAS 457081-03-7-Calbiochem
2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, P6, Pyridone 6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X
基本信息
Empirical Formula【经验(实验)分子式】 | C18H16FN3O |
Molecular weight | 309.34 |
General description【一般描述】 | A potent inhibitor of Janus Protein tyrosine Kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC50 = 15 nM for murine JAK1), JAK2 IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk2 (IC50 = 1 nM). It inhibits other kinases only at much higher concentrations. Also inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks the phosphorylation of STAT5. |
Biochem/physiol Actions【生化/生理作用】 | Target Ki: 5 nM against JAK3 Reversible: yes Cell permeable: yes Primary Target murine JAK1 Product competes with ATP. Target IC50: 15 nM, 1 nM against murine JAK1 and JAK2, respectively; 1 nM against Tyk2 |
Warning【警告】 | Toxicity: Irritant (B) |
Physical form【外形】 | A 10 mM (500 µg/162 µl) solution of JAK Inhibitor I (Cat. No. 420099) in DMSO. |
Reconstitution【重悬】 | Following initial use, aliquot and refrigerate (4°C). |
Other Notes【其他说明】 | Thompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett.12, 1219. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥98% (HPLC) |
form【形式】 | liquid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | 2-8℃ |
packaging【包装】 | 500 μg in Plastic ampoule Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 2 |
Flash Point(F)【闪点(F)】 | 188.6 °F - (Dimethylsulfoxide) |
Flash Point(C)【闪点(C)】 | 87 ℃ - (Dimethylsulfoxide) |