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InSolution JAK Inhibitor I-CAS 457081-03-7-Calbiochem

产品编号:4145194
规格:The InSolution JAK Inhibitor I, also referenced under CAS 457081-03-7, controls the biological activity of JAK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
CAS NO:457081-03-7
包装规格:500 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
4145194500 μG2150
产品别名

457081-03-7

InSolution JAK Inhibitor I-CAS 457081-03-7-Calbiochem

2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, P6, Pyridone 6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X

基本信息
Empirical Formula【经验(实验)分子式】
C18H16FN3O
Molecular weight
309.34
General description【一般描述】
A potent inhibitor of Janus Protein tyrosine Kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC50 = 15 nM for murine JAK1), JAK2 IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk2 (IC50 = 1 nM). It inhibits other kinases only at much higher concentrations. Also inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks the phosphorylation of STAT5.
Biochem/physiol Actions【生化/生理作用】
Target Ki: 5 nM against JAK3
Reversible: yes
Cell permeable: yes
Primary Target
murine JAK1
Product competes with ATP.
Target IC50: 15 nM, 1 nM against murine JAK1 and JAK2, respectively; 1 nM against Tyk2
Warning【警告】
Toxicity: Irritant (B)
Physical form【外形】
A 10 mM (500 µg/162 µl) solution of JAK Inhibitor I (Cat. No. 420099) in DMSO.
Reconstitution【重悬】
Following initial use, aliquot and refrigerate (4°C).
Other Notes【其他说明】
Thompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett.12, 1219.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
liquid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
desiccated (hygroscopic)
protect from light
shipped in【运输】
wet ice
storage temp.【储存温度】
2-8℃
packaging【包装】
500 μg in Plastic ampoule
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)【闪点(F)】
188.6 °F - (Dimethylsulfoxide)
Flash Point(C)【闪点(C)】
87 ℃ - (Dimethylsulfoxide)
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