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InSolution GSK-3 Inhibitor IX-CAS 667463-62-9-Calbiochem

产品编号:4145192
规格:The InSolution GSK-3 Inhibitor IX, also referenced under CAS 667463-62-9, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
CAS NO:667463-62-9
包装规格:500 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
4145192500 μG1940
产品别名

667463-62-9

InSolution GSK-3 Inhibitor IX-CAS 667463-62-9-Calbiochem

基本信息
Empirical Formula【经验(实验)分子式】
C16H10BrN3O2
Molecular weight
356.17
MDL number
MFCD08705318
General description【一般描述】
A cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Specificity was confirmed using various Cdk′s (IC50 = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC50 ≥ 10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs).
Biochem/physiol Actions【生化/生理作用】
Cell permeable: yes
Reversible: no
Product competes with ATP.
Target IC50: 5 nM against GSK-3α/β
Warning【警告】
Toxicity: Carcinogenic / Teratogenic (D)
Physical form【外形】
A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.
Other Notes【其他说明】
Polychronopoulos, P., et al. 2004. J. Med. Chem.47, 935.
Sato, N., et al. 2004. Nat. Med.10, 55.
Meijer, L., et al. 2003. Chem. Biol.10, 1255.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥97% (HPLC)
form【形式】
liquid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
desiccated (hygroscopic)
protect from light
shipped in【运输】
wet ice
storage temp.【储存温度】
2-8℃
packaging【包装】
500 μg in Plastic ampoule
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 2
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