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InSolution GSK-3 Inhibitor IX-CAS 667463-62-9-Calbiochem
产品编号: | 4145192 |
规格: | The InSolution |
CAS NO: | 667463-62-9 |
包装规格: | 500 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4145192 | 500 μG | 1940 |
产品别名
667463-62-9
InSolution GSK-3 Inhibitor IX-CAS 667463-62-9-Calbiochem
基本信息
Empirical Formula【经验(实验)分子式】 | C16H10BrN3O2 |
Molecular weight | 356.17 |
MDL number | MFCD08705318 |
General description【一般描述】 | A cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Specificity was confirmed using various Cdk′s (IC50 = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC50 ≥ 10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs). |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Reversible: no Product competes with ATP. Target IC50: 5 nM against GSK-3α/β |
Warning【警告】 | Toxicity: Carcinogenic / Teratogenic (D) |
Physical form【外形】 | A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO. |
Other Notes【其他说明】 | Polychronopoulos, P., et al. 2004. J. Med. Chem.47, 935. Sato, N., et al. 2004. Nat. Med.10, 55. Meijer, L., et al. 2003. Chem. Biol.10, 1255. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥97% (HPLC) |
form【形式】 | liquid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | 2-8℃ |
packaging【包装】 | 500 μg in Plastic ampoule Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 2 |