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InSolution β-Secretase Inhibitor IV-CAS 797035-11-1-Calbiochem
产品编号: | 4145189 |
规格: | The InSolution |
CAS NO: | 797035-11-1 |
包装规格: | 500 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4145189 | 500 μG | 2360 |
产品别名
797035-11-1
InSolution β-Secretase Inhibitor IV-CAS 797035-11-1-Calbiochem
N-(1 S, 2 R)-1-Benzyl-3-(cyclopropylamino)-2-hydroxypropyl)-5-(methyl(methylsulfonyl)amino-N'-((1 R)-1-phenylethyl)isophthalamide
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C31H38N4O5S |
Molecular weight | 578.72 |
MDL number | MFCD09037559 |
General description【一般描述】 | A cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). The solid form of this compound (Cat. No. 565788) is also available. |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target β-Secretase Target IC50: 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells Reversible: yes |
Warning【警告】 | Toxicity: Irritant (B) |
Physical form【外形】 | A 10 mM (500 µg/86.4 µL) solution of β-Secretase Inhibitor IV (Cat. No. 565788) in DMSO. |
Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. For short term storage, aliquots are stable for up to 3 months at -20°C. |
Other Notes【其他说明】 | Stachel, S.J., et al. 2004. J. Med. Chem.47, 6447. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥95% (HPLC) |
form【形式】 | liquid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −70℃ |
SMILES string | O=C(C1=CC(C(N[C@@H](CC2=CC=CC=C2)[C@H](O)CNC3CC3)=O)=CC(N(S(C)(=O)=O)C)=C1)N[C@H](C)C4=CC=CC=C4 |
packaging【包装】 | 500 μg in Glass bottle Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |
Flash Point(F)【闪点(F)】 | 188.6 °F - (refers to pure substance) |
Flash Point(C)【闪点(C)】 | 87 ℃ - (refers to pure substance) |