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InSolution β-Secretase Inhibitor IV-CAS 797035-11-1-Calbiochem

产品编号:4145189
规格:The InSolution β-Secretase Inhibitor, also referenced under CAS 797035-11-1, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
CAS NO:797035-11-1
包装规格:500 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
4145189500 μG2360
产品别名

797035-11-1

InSolution β-Secretase Inhibitor IV-CAS 797035-11-1-Calbiochem

N-(1 S, 2 R)-1-Benzyl-3-(cyclopropylamino)-2-hydroxypropyl)-5-(methyl(methylsulfonyl)amino-N'-((1 R)-1-phenylethyl)isophthalamide

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C31H38N4O5S
Molecular weight
578.72
MDL number
MFCD09037559
General description【一般描述】
A cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). The solid form of this compound (Cat. No. 565788) is also available.
Biochem/physiol Actions【生化/生理作用】
Cell permeable: yes
Primary Target
β-Secretase
Target IC50: 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells
Reversible: yes
Warning【警告】
Toxicity: Irritant (B)
Physical form【外形】
A 10 mM (500 µg/86.4 µL) solution of β-Secretase Inhibitor IV (Cat. No. 565788) in DMSO.
Reconstitution【重悬】
Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. For short term storage, aliquots are stable for up to 3 months at -20°C.
Other Notes【其他说明】
Stachel, S.J., et al. 2004. J. Med. Chem.47, 6447.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95% (HPLC)
form【形式】
liquid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
SMILES string
O=C(C1=CC(C(N[C@@H](CC2=CC=CC=C2)[C@H](O)CNC3CC3)=O)=CC(N(S(C)(=O)=O)C)=C1)N[C@H](C)C4=CC=CC=C4
packaging【包装】
500 μg in Glass bottle
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)【闪点(F)】
188.6 °F - (refers to pure substance)
Flash Point(C)【闪点(C)】
87 ℃ - (refers to pure substance)
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