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IKK-2 Inhibitor IV-CAS 507475-17-4-Calbiochem
产品编号: | 4145176 |
规格: | The IKK-2 Inhibitor IV, also referenced under CAS 507475-17-4, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. |
CAS NO: | 507475-17-4 |
包装规格: | 500 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4145176 | 500 μG | 2090 |
产品别名
507475-17-4
IKK-2 Inhibitor IV-CAS 507475-17-4-Calbiochem
[5-( p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide, TPCA-1
基本信息
Empirical Formula【经验(实验)分子式】 | C12H10FN3O2S |
Molecular weight | 279.29 |
MDL number | MFCD09037541 |
General description【一般描述】 | A cell-permeable ureidocarboxamido thiophene compound that acts as a potent, reversible, and ATP-competitive inhibitor of IKK-2 (IC50 = 18 nM) with selectivity over IKK-1, JNK and p38 MAPK. Inhibits TNF-α production in human monocytes (IC50 in the range of 0.15-2.5 µM) and blocks IL-8 and IL-6 production by synovial fibroblasts (IC50 = 100 nM). Further reduces paw oedema in rat arthritis model (~100% inhibition at a dose of 30 mg per kg). A 10 mM (500 µg/179 µl) solution of IKK-2 Inhibitor IV (Cat. No. 401484) in DMSO is available. A cell-permeable, reversible, ATP-competitive, and potent inhibitor of IKK-2 (IC50 = 18 nM) that exhibits selectivity over IKK-1, JNK, and p38 MAPK. Inhibits TNF-α production in human monocytes (IC50 in the range of 0.15-2.5 µM) and blocks IL-8 and IL-6 production by synovial fibroblasts (IC50 = 100 nM). Shown to reduce paw oedema in rat arthritis model (~100% inhibition at a dose of 30 mg per kg). |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Target IC50: 18 nM against IKK-2 Primary Target IKK-2 Product competes with ATP. Reversible: yes |
Warning【警告】 | Toxicity: Standard Handling (A) |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
Other Notes【其他说明】 | Podolin, P.L., et al. 2005. J. Pharmacol. Exp. Ther.312, 373. Karin, M., et al. 2004. Nat. Rev. Drug Discov.3, 17. Roshak, A.K., et al. 2002. Inflamm. Res.51, S4. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥95% (HPLC) |
form【形式】 | solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | pale yellow |
solubility【溶解性】 | DMSO: 10 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | 2-8℃ |
packaging【包装】 | 500 μg in Plastic ampoule Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |