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Histone Deacetylase 8, His·Tag®, Human Recombinant, S. frugiperda

产品编号:4145149
规格:Histone Deacetylase 8, His·Tag, Human Recombinant, S. frugiperda, is a full length HDAC8 fused to His-Tag at the C-terminus. Useful in the study of HDAC8 regulation and for inhibitor screening.
包装规格:50 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
414514950 μG9050
产品别名

Histone Deacetylase 8, His·Tag®, Human Recombinant, S. frugiperda

HDAC8, Human, Recombinant

产品性质
recombinant【重组】
expressed in insect cells (S. frugiperda)
Quality Level【质量水平】
100
Assay【测定】
≥90% (SDS-PAGE)
form【形式】
liquid
Specific Activity
≥10 units/μg protein
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
avoid repeated freeze/thaw cycles
shipped in【运输】
wet ice
storage temp.【储存温度】
−70℃
packaging【包装】
50 μg in Plastic ampoule
Please refer to vial label for lot-specific concentration.
基本信息
General description【一般描述】
Full length, recombinant, human histone deacetylase 8 (HDAC8) fused to at the C-terminus to a His•Tag sequence at and expressed in S. frugiperda insect cells using a baculovirus expression system. HDAC8 phosphorylated in vivo by PKA results in decreased activity, which leads to the hyperacetylation of histones H3 and H4. HDAC8 may play a role in one of the most frequent types of acute myeloid leukemia (AML). The active deacetylase is useful in the study of HDAC8 regulation and for inhibitor screening.
Warning【警告】
Toxicity: Standard Handling (A)
Unit Definition【单位定义】
One unit is defined as the the amount of enzyme required to deacetylate 1 picomol fluorescent peptide substrate [Arg-His-Lys(Ac)-Lys(Ac)] per min at 30°C.
Physical form【外形】
In 138 mM NaCl, 25 mM Tris-HCl, 10% glycerol, 0.05% TWEEN®-20 detergent, pH 8.0.
Reconstitution【重悬】
Following initial thaw, aliquot and freeze (-70°C).
Other Notes【其他说明】
Waltregny, D., et al. 2005. FASEB J.19, 966.
Buggy, J.J., et al. 2000. Biochem J. 350, 199
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany
TWEEN is a registered trademark of Croda International PLC
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
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