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GST A3-3, Recombinant Human
产品别名
GST A3-3, Recombinant Human
glutathione S-transferase alpha 3
GTA3
基本信息
NACRES | NA.26 |
Biochem/physiol Actions【生化/生理作用】 | Glutathione S-transferase alpha 3 (GSTA3) is an enzyme that in humans is encoded by the GSTA3 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. |
产品性质
biological source【生物来源】 | human |
recombinant【重组】 | expressed in E. coli |
Assay【测定】 | >95% (SDS-PAGE) |
form【形式】 | frozen liquid |
Specific Activity | 61 U/mg (using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1 mM) in 100 mM NaPO4 (pH 6.5) at room temperature.) |
mol wt【分子量】 | 25 kDa |
concentration【浓度】 | 1.0 mg/mL |
storage temp.【储存温度】 | −70℃ |
Gene Information | human ... GSTA3(2940) |
产品说明
Storage and Stability【储存及稳定性】 | The enzyme should be used by the end-user customer within 1 year of receipt. |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |