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GST A2-2, Recombinant Human
产品别名
GST A2-2, Recombinant Human
GST2
GTH2
GTA2
glutathione S-transferase alpha 2
基本信息
NACRES | NA.26 |
Biochem/physiol Actions【生化/生理作用】 | The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual′s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. Glutathione S-transferase alpha 2 (GSTA2) is an enzyme that in humans is encoded by the GSTA2 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | human |
recombinant【重组】 | expressed in E. coli |
Assay【测定】 | >95% (SDS-PAGE) |
form【形式】 | frozen liquid |
Specific Activity | 15.95 units/mg protein (using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1 mM) in 100 mM NaPO4 (pH 6.5) at 30℃.) |
mol wt【分子量】 | 23 kDa |
concentration【浓度】 | 1.52 mg/mL |
storage temp.【储存温度】 | −70℃ |
Gene Information | human ... GSTA2(2939) |
产品说明
Storage and Stability【储存及稳定性】 | The enzyme should be used by the end-user customer within 1 year of receipt. |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |