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GST A1-1, Recombinant Human
产品别名
GST A1-1, Recombinant Human
GST2
Glutathione S-transferase alpha 1
GTH1
GSTA1-1
GST-epsilon
基本信息
NACRES | NA.26 |
Biochem/physiol Actions【生化/生理作用】 | Glutathione S-transferase alpha 1 (GSTA1) is an enzyme that in humans is encoded by the GSTA1 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. The GSTA1 gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | human |
recombinant【重组】 | expressed in E. coli |
Assay【测定】 | >95% (SDS-PAGE) |
form【形式】 | frozen liquid |
Specific Activity | 21.04 units/mg protein (using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1 mM) in 100 mM NaPO4 (pH 6.5) at room temperature.) |
mol wt【分子量】 | 23 kDa |
concentration【浓度】 | 2.0 mg/mL |
storage temp.【储存温度】 | −70℃ |
Gene Information | human ... GSTA1(2938) |
产品说明
Storage and Stability【储存及稳定性】 | The enzyme should be used by the end-user customer within 1 year of receipt. |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |