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Calpastatin Peptide-Calbiochem
产品编号: | 4144270 |
规格: | A 27-amino acid, cell-permeable peptide encoded by exon 1B of human calpastatin that acts as a potent inhibitor of calpain I and calpain II (IC50 = 20 nM for purified rabbit calpain II). |
包装规格: | 500 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Calpastatin Peptide-Calbiochem
CS Peptide
基本信息
Empirical Formula【经验(实验)分子式】 | C142H230N36O44S |
Molecular weight | 3177.63 |
General description【一般描述】 | A 27-amino acid, peptide encoded by exon 1B of human calpastatin that acts as a cell-permeable and potent inhibitor of calpain I and calpain II (IC50 = 20 nM for purified rabbit calpain II). Does not inhibit either papain or trypsin. Blocks the down-regulation of protein kinase Cε (PKCε) in rat pituitary GH4C1 cells stimulated by thyrotropin-releasing hormone (TRH). A 27-amino acid, cell-permeable peptide encoded by exon 1B of human calpastatin that acts as a potent inhibitor of calpain I and calpain II (IC50 = 20 nM for purified rabbit calpain II). Does not inhibit either papain or trypsin. Blocks the down-regulation of protein kinase Cε (PKCε) in rat pituitary GH4C1 cells stimulated by thyrotropin-releasing hormone (TRH). |
Biochem/physiol Actions【生化/生理作用】 | Product does not compete with ATP. Cell permeable: yes Target IC50: 20 nM against calpain II Reversible: no Primary Target calpain 2 |
Warning【警告】 | Toxicity: Standard Handling (A) |
Sequence【序列】 | Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH₂ |
Physical form【外形】 | Supplied as a trifluoroacetate salt. |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
Other Notes【其他说明】 | Eto, A., et al. 1995. J. Biol. Chem. 270, 25115. Kawasaki, J., et al. 1989. J. Biochem. 106, 274. Maki, M., et al. 1989. J. Biol. Chem. 264, 18866. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥95% (HPLC) |
form【形式】 | lyophilized solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
color【颜色】 | white |
solubility【溶解性】 | 1% acetic acid: 1 mg/mL water: 1 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | −20℃ |
packaging【包装】 | 500 μg in Glass bottle |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 1 |