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β-Secretase Inhibitor III-Calbiochem

产品编号:4144124
规格:The β-Secretase Inhibitor III controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
包装规格:500 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4144124500 μG2570
产品别名

β-Secretase Inhibitor III-Calbiochem

Inhibitor GL189, H-EVNstatineVAEF-NH2

基本信息
Empirical Formula【经验(实验)分子式】
C44H70N10O14
Molecular weight
963.09
General description【一般描述】
A substrate analog inhibitor of β-secretase (BACE) that completely blocks proteolytic activity in solubilized membrane fractions of BACE-transfected MDCK cells at a concentration of 5 µM.
A substrate analog inhibitor of β-secretase (BACE) that completely blocks the proteolytic activity (at 5 µM) in solubilized membrane fractions from BACE transfected MDCK cells.
Biochem/physiol Actions【生化/生理作用】
Product does not compete with ATP.
Primary Target
BACE
Reversible: no
Effective concentration: 5 µM completely blocking the proteolytic activity of β-secretase (BACE) in solubilized membrane fractions from BACE transfected MDCK cells
Cell permeable: no
Warning【警告】
Toxicity: Standard Handling (A)
Sequence【序列】
H-Glu-Val-Asn-Statine-Val-Ala-Glu-Phe-NH₂
Physical form【外形】
Supplied as a trifluoroacetate salt.
Reconstitution【重悬】
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes【其他说明】
Capell, A., et al. 2002. J. Biol. Chem.277, 5637.
Tung, J.S., et al. 2002. J. Med. Chem.45, 259.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95% (HPLC)
form【形式】
lyophilized
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
desiccated (hygroscopic)
solubility【溶解性】
DMSO: 1 mg/mL
shipped in【运输】
ambient
storage temp.【储存温度】
−20℃
packaging【包装】
500 μg in Plastic ampoule
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 1
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